XL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does XL mean? 

• XL (noun)
  The noun XL has 1 sense:

1. the cardinal number that is the product of ten and four

  Familiarity information: XL used as a noun is very rare.

• XL (adjective)
  The adjective XL has 1 sense:

1. being ten more than thirty

  Familiarity information: XL used as an adjective is very rare.

 Dictionary entry details 

• XL (noun)

Sense 1

Meaning:

The cardinal number that is the product of ten and four

Classified under:

Nouns denoting quantities and units of measure

Synonyms:

40; forty; XL

Hypernyms ("XL" is a kind of...):

large integer (an integer equal to or greater than ten)

• XL (adjective)

Sense 1

Meaning:

Being ten more than thirty

Synonyms:

40; forty; twoscore; xl

Similar:

cardinal (being or denoting a numerical quantity but not order)

 Context examples 

Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2.

(BAD Regulation Pathway, NCI Thesaurus/BIOCARTA)

Bcl-Xs block the function of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid tumors and promote cancer cell survival by inhibiting apoptosis.

(Bcl-Xs Adenovirus Vaccine, NCI Thesaurus)

The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.

(Obatoclax mesylate, NCI Thesaurus)

Inhibition of these apoptosis suppressors prevents their binding to the apoptotic effectors Bax and Bak proteins, thereby triggering apoptotic processes in cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

(Navitoclax, NCI Thesaurus)

BikDD binds with greater affinity to anti-apoptotic proteins bcl-2, bcl-xl, bcl-w and Mcl-1 and is more potent than wild-type Bik.

(C-VISA BikDD:Liposome, NCI Thesaurus)

Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1.

(Atiprimod Dihydrochloride, NCI Thesaurus)

PEITC also inhibits the expression of genes involved in tumor progression such as HIF, STAT-3, HER2, BCL-XL, and XIAP and induces the expression of genes involved in tumor suppression such as p53, ATF-2, and p57.

(Phenethyl Isothiocyanate-containing Watercress Juice, NCI Thesaurus)

Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1.

(Atiprimod Dimaleate, NCI Thesaurus)

Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.

(Atiprimod, NCI Thesaurus)

Vaccination with Bcl-Xs adenovirus vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in decreased tumor growth while leaving normal cells unaffected.

(Bcl-Xs Adenovirus Vaccine, NCI Thesaurus)