XENOGRAFT

Pronunciation (US):

(GB):

 Dictionary entry overview: What does xenograft mean? 

• XENOGRAFT (noun)
  The noun XENOGRAFT has 1 sense:

1. tissue from an animal of one species used as a temporary graft (as in cases of severe burns) on an individual of another species

  Familiarity information: XENOGRAFT used as a noun is very rare.

 Dictionary entry details 

• XENOGRAFT (noun)

Sense 1

Meaning:

Tissue from an animal of one species used as a temporary graft (as in cases of severe burns) on an individual of another species

Classified under:

Nouns denoting body parts

Synonyms:

heterograft; xenograft

Hypernyms ("xenograft" is a kind of...):

graft; transplant ((surgery) tissue or organ transplanted from a donor to a recipient; in some cases the patient can be both donor and recipient)

 Context examples 

Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts.

(Lapatinib, NCI Thesaurus)

Animals with transplanted human cancers or other tissues are called xenograft models.

(Animal model, NCI Dictionary)

GalT catalyzes the expression of foreign alpha-1,3-galactosyl (alpha-gal) carbohydrate epitopes in glycoproteins and in glycolipids on the cell membranes of the allogeneic lung tumor cells present in the vaccine, essentially producing a 'xenograft'.

(Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Lung Tumor Cell Vaccine, NCI Thesaurus)

The hyperacute rejection involves pre-existing human anti-alpha-gal antibodies that bind the foreign alpha-gal epitopes expressed by the vaccine tumor cell xenograft, resulting in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) towards endogenous lung tumor cells with unmodified carbohydrate epitopes.

(Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Lung Tumor Cell Vaccine, NCI Thesaurus)