X-SCID

Pronunciation (US):

(GB):

 Dictionary entry overview: What does X-SCID mean? 

• X-SCID (noun)
  The noun X-SCID has 1 sense:

1. SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor

  Familiarity information: X-SCID used as a noun is very rare.

 Dictionary entry details 

• X-SCID (noun)

Sense 1

Meaning:

SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor

Classified under:

Nouns denoting stable states of affairs

Synonyms:

X-linked SCID; X-SCID

Hypernyms ("X-SCID" is a kind of...):

SCID; severe combined immunodeficiency; severe combined immunodeficiency disease (a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life)

 Context examples 

To restore immune function to those with X-SCID, scientists developed an experimental gene therapy that involves inserting a normal copy of the IL2RG gene into the patient’s own blood-forming stem cells.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)

The Phase 1/2 trial reported today enrolled eight infants aged 2 to 14 months who were newly diagnosed with X-SCID and lacked a genetically matched sibling donor.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)

Infants with X-SCID typically are treated with transplants of blood-forming stem cells, ideally from a genetically matched sibling.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)

Infants with X-SCID, caused by mutations in the IL2RG gene, are highly susceptible to severe infections.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)

The new approach appears safer and more effective than previously tested gene-therapy strategies for X-SCID.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)

Eight infants with the disorder, called X-linked severe combined immunodeficiency (X-SCID), received an experimental gene therapy co-developed by National Institutes of Health scientists.

(Gene therapy restores immunity in infants with rare immunodeficiency disease, National Institutes of Health)