VALINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does valine mean? 

• VALINE (noun)
  The noun VALINE has 1 sense:

1. an essential amino acid found in proteins; important for growth in children and nitrogen balance in adults

  Familiarity information: VALINE used as a noun is very rare.

 Dictionary entry details 

• VALINE (noun)

Sense 1

Meaning:

An essential amino acid found in proteins; important for growth in children and nitrogen balance in adults

Classified under:

Nouns denoting substances

Hypernyms ("valine" is a kind of...):

essential amino acid (an amino acid that is required by animals but that they cannot synthesize; must be supplied in the diet)

 Context examples 

A change in the valine at position 600 of the serine/threonine-protein kinase B-raf protein to another amino acid.

(BRAF V600 Protein Variation, NCI Thesaurus)

This allele, which encodes valacyclovir hydrolase protein, is involved in the activation of valine ester prodrugs and other amino acid ester prodrugs of nucleoside analogs.

(BPHL wt Allele, NCI Thesaurus)

In newition to production from fatty acids, propionyl-CoA is derived from the metabolism of several fatty acids, including isoleucine, valine and methionine.

(Oxidation of Odd-Numbered Chain Fatty Acid Pathway, NCI Thesaurus/BIOCARTA)

A synthetic form of the K-ras protein containing a point mutation at position 12 (glycine to valine).

(K-RAS VAL-12 Mutant Protein, NCI Thesaurus)

A recombinant peptide derived from the human melanoma antigen glycoprotein 100 (gp100) with potential use in cancer immunotherapy. gp100 protein(184V) has a valine substitution at position 184.

(gp100 Protein (184V), NCI Thesaurus)

The valine to glutamic acid substitution at residue 600 (V600E) accounts for about 90% of BRAF gene mutations.

(BRAF Inhibitor ARQ 736, NCI Thesaurus)

The valine to glutamic acid substitution at residue 600 accounts for about 90% of BRAF gene mutations; the oncogenic product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway.

(BRAF(V600E) Kinase Inhibitor RO5212054, NCI Thesaurus)

The Raf mutation BRAF V600E, in which valine is substituted for glutamic acid at residue 600, is frequently found in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.

(BRAF(V600E) Inhibitor CEP-32496, NCI Thesaurus)

A peptide vaccine consisting of the amino acids 280 through 288 of the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity. gp100:280-288(288V) peptide has a valine substitution at amino acid position 288 to improve immunogenicity.

(gp100:280-288(288V) Peptide Vaccine, NCI Thesaurus)

Modified at position 165 (cysteine to valine) to improve immunogenicity, ESO-1:157-165(165v) peptide administered as a vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for ESO-1, resulting in decreased tumor growth.

(ESO-1:157-165(165V) Peptide, NCI Thesaurus)