VACCINIA

Pronunciation (US):

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 Dictionary entry overview: What does vaccinia mean? 

• VACCINIA (noun)
  The noun VACCINIA has 2 senses:

1. a local infection induced in humans by inoculation with the virus causing cowpox in order to confer resistance to smallpox; normally lasts three weeks and leaves a pitted scar

2. a viral disease of cattle causing a mild skin disease affecting the udder; formerly used to inoculate humans against smallpox

  Familiarity information: VACCINIA used as a noun is rare.

 Dictionary entry details 

• VACCINIA (noun)

Sense 1

Meaning:

A local infection induced in humans by inoculation with the virus causing cowpox in order to confer resistance to smallpox; normally lasts three weeks and leaves a pitted scar

Classified under:

Nouns denoting stable states of affairs

Synonyms:

vaccina; vaccinia; variola vaccina; variola vaccine; variola vaccinia

Hypernyms ("vaccinia" is a kind of...):

infection (the pathological state resulting from the invasion of the body by pathogenic microorganisms)

Hyponyms (each of the following is a kind of "vaccinia"):

progressive vaccinia; vaccinia gangrenosa (a severe or even fatal form of vaccinia that occurs mainly in persons with an immunological deficiency; characterized by progressive enlargement of the initial lesion)

Sense 2

Meaning:

A viral disease of cattle causing a mild skin disease affecting the udder; formerly used to inoculate humans against smallpox

Classified under:

Nouns denoting stable states of affairs

Synonyms:

cowpox; vaccinia

Hypernyms ("vaccinia" is a kind of...):

pox (a contagious disease characterized by purulent skin eruptions that may leave pock marks)

animal disease (a disease that typically does not affect human beings)

 Context examples 

In addition, ALVAC(2) encodes the vaccinia virus (vv) E3L ad K3L genes, which may potentiate the translation of the NY-ESO and TRICOM genes.

(ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine, NCI Thesaurus)

A cancer vaccine made with a form of vaccinia virus that does not cause disease in humans.

(Inalimarev, NCI Dictionary)

A vaccinia viral based vaccine, encoding epitopes of E6 and E7 proteins from human papillomavirus (HPV) types 16 and 18, with immunostimulatory and antineoplastic activities.

(Human Papillomavirus Tumor Antigen Vaccine, NCI Thesaurus)

In cancer gene therapy, inactivated vaccinia virus may be used as a vector to express a protein that kills tumor cells or elicits specific anti-tumor immunity.

(Inactivated Vaccinia Virus, NCI Thesaurus)

A cancer vaccine consisting of a proprietary, recombinant modified vaccinia Ankara (MVA) viral vector encoding an epitope of human epidermal growth factor receptor 2 (HER2) with potential antineoplastic activity.

(Modified Vaccinia Ankara (Bavarian Nordic)-HER2 Vaccine, NCI Thesaurus)

A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the suicide gene FCU1 with potential antineoplastic activity.

(MVA-FCU1 TG4023, NCI Thesaurus)

A thymidine kinase-deleted vaccinia virus expressing human GM-CSF (hGM-CSF) with oncolytic activity.

(Pexastimogene-devacirepvec, NCI Thesaurus)

A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities.

(MVA-MUC1-IL2 Vaccine, NCI Thesaurus)

Upon administration, light-emitting oncolytic vaccinia virus GL-ONC1 specifically enters tumor cells due to the permeable nature of the tumor vasculature.

(Light-Emitting Oncolytic Vaccinia Virus GL-ONC1, NCI Thesaurus)

A cancer vaccine consisting of a recombinant vaccinia virus encoding the gp100 melanoma-melanocyte antigen. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas.

(gp100 Vaccinia Vaccine, NCI Thesaurus)