URACIL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does uracil mean? 

• URACIL (noun)
  The noun URACIL has 1 sense:

1. a base containing nitrogen that is found in RNA (but not in DNA) and derived from pyrimidine; pairs with adenine

  Familiarity information: URACIL used as a noun is very rare.

 Dictionary entry details 

• URACIL (noun)

Sense 1

Meaning:

A base containing nitrogen that is found in RNA (but not in DNA) and derived from pyrimidine; pairs with adenine

Classified under:

Nouns denoting substances

Synonyms:

U; uracil

Hypernyms ("uracil" is a kind of...):

base; nucleotide (a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA))

Holonyms ("uracil" is a substance of...):

ribonucleic acid; RNA ((biochemistry) a long linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell)

 Context examples 

A tablet formulation containing 5-ethynyluracil (GW776), an ethynyl derivative of uracil and the antineoplastic agent 5-Fluorouracil (5-FU) in a 10:1 ratio.

(GW776/5-Fluorouracil Combination Tablet, NCI Thesaurus)

It is a type of uracil analog.

(FAU, NCI Dictionary)

It is a combination of tegafur and uracil.

(Ftorafur, NCI Dictionary)

CldUMP, the active metabolite, incorporates into DNA and, upon exposure to radiation, induces the formation of uracil radicals and double-strand DNA breaks.

(Cytochlor, NCI Thesaurus)

Then, the amplified DNA is treated with bisulfite twice under denaturing conditions, which converts non-methylated cytosine residues to uracil.

(MethylC-Seq, NCI Thesaurus)

FCU1 is a bifunctional yeast cytosine deaminase (CD) / uracil phosphoribosyltransferase (UPRT) fusion gene.

(MVA-FCU1 TG4023, NCI Thesaurus)

In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth.

(Fluorouracil, NCI Thesaurus)

This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis.

(Floxuridine, NCI Thesaurus)

A uracil nucleotide comprised of three phosphate groups esterified to the deoxyribose sugar moiety.

(Deoxyuridine Triphosphate, NCI Thesaurus)

After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis.

(Flucytosine, NCI Thesaurus)