UNCOUPLE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does uncouple mean? 

• UNCOUPLE (verb)
  The verb UNCOUPLE has 1 sense:

1. disconnect or separate

  Familiarity information: UNCOUPLE used as a verb is very rare.

 Dictionary entry details 

• UNCOUPLE (verb)

Present simple: I / you / we / they uncouple    ... he / she / it uncouples   
Past simple: uncoupled   
Past participle: uncoupled   
-ing form: uncoupling   

Sense 1

Meaning:

Disconnect or separate

Classified under:

Verbs of touching, hitting, tying, digging

Synonyms:

decouple; uncouple

Context example:

uncouple the hounds

Hypernyms (to "uncouple" is one way to...):

disconnect (make disconnected, disjoin or unfasten)

Sentence frames:

Somebody ----s something
Something ----s something

Antonym:

couple (link together)

 Context examples 

A mitochondrial uncoupling protein is found in brown adipose tissue.

(Electron Transport Pathway, NCI Thesaurus/BIOCARTA)

Mitochondrial brown fat uncoupling protein 1 (307 aa, ~33 kDa) is encoded by the human UCP1 gene.

(Mitochondrial Brown Fat Uncoupling Protein 1, NCI Thesaurus)

They then identified specific populations of cells with a protein marker of brown fat cells known as uncoupling protein 1 (UCP1).

(Insights into Energy-Burning Fat Cells, NIH)

BAT is a thermogenic organ equipped to dissipate energy in the form of heat through the so-called “uncoupling protein”.

(Increasing the level of physical activity is found not to improve the functioning of brown adipose tissue, University of Granada)

The precise mechanism of antitumor action has not yet been elucidated, however, certain diarylsulfonylurea compounds have been shown in preliminary studies to exert antimitotic effects through their inhibition of tubulin polymerization, and others have been shown to be effective antitumor agents in animal models by the mechanism of uncoupling mitochondrial oxidative phosphorylation.

(Diarylsulfonylurea Compound, NCI Thesaurus)

Proteins also can act as uncoupling agents in the mitochondria.

(Electron Transport Pathway, NCI Thesaurus/BIOCARTA)

Uncoupling agents allow protons to flow across the mitochondrial membrane without producing ATP.

(Electron Transport Pathway, NCI Thesaurus/BIOCARTA)

An increase in the activity of uncoupling proteins increases heat production by allowing protons to flow down their gradient without making ATP and may serve as protection against cold, as well as a potential means of obesity control.

(Electron Transport Pathway, NCI Thesaurus/BIOCARTA)