TUMOR NECROSIS FACTOR

Pronunciation (US):

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 Dictionary entry overview: What does tumor necrosis factor mean? 

• TUMOR NECROSIS FACTOR (noun)
  The noun TUMOR NECROSIS FACTOR has 1 sense:

1. a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

  Familiarity information: TUMOR NECROSIS FACTOR used as a noun is very rare.

 Dictionary entry details 

• TUMOR NECROSIS FACTOR (noun)

Sense 1

Meaning:

A proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

Classified under:

Nouns denoting substances

Synonyms:

TNF; tumor necrosis factor; tumour necrosis factor

Hypernyms ("tumor necrosis factor" is a kind of...):

cytokine (any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system)

 Context examples 

The researchers determined that the children with otulipenia might respond to drugs that turned off tumor necrosis factor, a chemical messenger involved in systemic inflammation.

(Researchers discover otulipenia, a new inflammatory disease, NIH)

This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling.

(BCL2-associated Athanogene 4, NCI Thesaurus/LocusLink)

Also called tumor vasculature–targeted tumor necrosis factor alpha.

(NGR-TNF, NCI Dictionary)

Picibanil activates the host immune system by stimulating the activity of natural killer cells, macrophages and lymphocytes, and by enhancing the production of several key immune mediators, including interleukins and tumor necrosis factor.

(Picibanil, NCI Thesaurus)

Drug treatment to reduce the activity of tumor necrosis factor, particulary to control inflammation in disease modalities.

(Anti-Tumor Necrosis Factor Therapy, NCI Thesaurus)

Also called colloidal gold-bound tumor necrosis factor and TNF-bound colloidal gold.

(Aurimmune, NCI Dictionary)

CD antigen expressed on surface of monocytes, macrophages, eosinophils, neutrophils; lipopolysaccharide receptor; signals production of tumor necrosis factor.

(Monocyte Differentiation Antigen CD14, NIH CRISP Thesaurus)

In addition to its pro-apoptotic effect, MCC activates monocytes and macrophages to produce various cytokines, including interleukin 6 (IL-6), IL-8, IL-12, IL-18, and tumor necrosis factor alpha (TNF-a).

(Mycobacterial Cell Wall-DNA Complex, NCI Thesaurus)

Fas antigen is a member of tumor necrosis factor family that mediates antibody-triggered apoptosis.

(Monoclonal Antibody 7C11, NCI Thesaurus)

Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may enhance natural killer (NK) cell activity, potentially boosting anti-tumor host immune responses.

(Agaricus blazei Murill Extract, NCI Thesaurus)