TRANSLOCATION

Pronunciation (US):

(GB):

 Dictionary entry overview: What does translocation mean? 

• TRANSLOCATION (noun)
  The noun TRANSLOCATION has 2 senses:

1. the transport of dissolved material within a plant

2. (genetics) an exchange of chromosome parts

  Familiarity information: TRANSLOCATION used as a noun is rare.

 Dictionary entry details 

• TRANSLOCATION (noun)

Sense 1

Meaning:

The transport of dissolved material within a plant

Classified under:

Nouns denoting natural processes

Hypernyms ("translocation" is a kind of...):

biological process; organic process (a process occurring in living organisms)

Sense 2

Meaning:

(genetics) an exchange of chromosome parts

Classified under:

Nouns denoting natural processes

Context example:

translocations can result in serious congenital disorders

Hypernyms ("translocation" is a kind of...):

biological process; organic process (a process occurring in living organisms)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

Derivation:

translocate (transfer (a chromosomal segment) to a new position)

 Context examples 

A fusion gene that results from a chromosomal translocation t(9;11)(q34;q23) which fuses exon 7 of the MLL gene to most of the FNBP1 gene.

(MLL/FNBP1 Fusion Gene, NCI Thesaurus)

Expression of a fusion protein that results from a t(8;21)(q22;q22) translocation, which involves the human genes RUNX1 and RUNX1T1 and is associated with acute myeloid leukemia.

(AML1-ETO Fusion Protein Expression, NCI Thesaurus)

Several acute leukemias are associated with the translocation t(4;11)(q21;q23) of the gene and the MLL gene.

(AFF1 wt Allele, NCI Thesaurus)

This gene is involved in transcriptional regulation and translocations in the gene are associated with acute leukemia.

(AFF1 Gene, NCI Thesaurus)

The most frequently seen genetic alteration is a t(2;5) translocation.

(Anaplastic large cell lymphoma, NCI Thesaurus/WHO)

It is characterized by the absence of the translocation involving the ALK gene and lacks expression of ALK fusion protein.

(Anaplastic Large Cell Lymphoma, ALK-Negative, NCI Thesaurus)

A chromosomal translocation t(1;22)(p13;q13) with the RBM15 gene is associated with acute megakaryoblastic leukemia.

(MKL1 wt Allele, NCI Thesaurus)

Several acute leukemias are associated with translocations of the gene.

(MLL wt Allele, NCI Thesaurus)

The gene is involved in a translocation t(11;11)(q23;23) with the MLL gene which is associated with acute leukemia.

(ARHGEF12 wt Allele, NCI Thesaurus)

A fusion gene that results from a chromosomal translocation t(11;19)(q23;p13.1) which fuses the first 7 exons of the MLL gene to most of the coding sequence of the ELL gene.

(MLL/ELL Fusion Gene, NCI Thesaurus)