TRANSLOCATE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does translocate mean? 

• TRANSLOCATE (verb)
  The verb TRANSLOCATE has 2 senses:

1. transfer (a chromosomal segment) to a new position

2. move from one place to another, especially of wild animals

  Familiarity information: TRANSLOCATE used as a verb is rare.

 Dictionary entry details 

• TRANSLOCATE (verb)

Present simple: I / you / we / they translocate    ... he / she / it translocates   
Past simple: translocated   
Past participle: translocated   
-ing form: translocating   

Sense 1

Meaning:

Transfer (a chromosomal segment) to a new position

Classified under:

Verbs of buying, selling, owning

Hypernyms (to "translocate" is one way to...):

shift; transfer (move around)

Sentence frame:

Somebody ----s something

Derivation:

translocation ((genetics) an exchange of chromosome parts)

Sense 2

Meaning:

Move from one place to another, especially of wild animals

Classified under:

Verbs of buying, selling, owning

Context example:

The endangered turtles were translocated to a safe environment

Hypernyms (to "translocate" is one way to...):

transfer (move from one place to another)

Sentence frame:

Somebody ----s something

 Context examples 

Epo stimulates JAK2 phosphorylation of I-kB, releasing NF-kB to translocate into the nucleus and activate transcription of neuroprotective genes.

(Erythropoietin Neuroprotection Pathway, NCI Thesaurus/BIOCARTA)

The FES gene is translocated in acute promyelocytic leukemia.

(FES wt Allele, NCI Thesaurus)

Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3.

(Erk1/Erk2 MAPK Signaling Pathway, NCI Thesaurus/BIOCARTA)

Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur.

(Desonide, NCI Thesaurus)

The 23 kDa fragment then translocates to the nucleus.

(D4-GDI Signaling Pathway, NCI Thesaurus/BIOCARTA)

As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2).

(Fludrocortisone Acetate, NCI Thesaurus)

Flunisolide is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins.

(Flunisolide, NCI Thesaurus)

One of these pathways leads to IkB kinase activation, IkB phosphorylation, and degradation, releasing the NF-kB heterodimer to translocate into the nucleus and activate transcription of target genes.

(NFKB Activation Pathway, NCI Thesaurus/BIOCARTA)

In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE).

(Nrf2 Activator RTA 408, NCI Thesaurus)

CaN dephosphorylates NF-ATc4 that translocates to the nucleus.

(NFAT Pathway, NCI Thesaurus/BIOCARTA)