TRANSDERMAL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does transdermal mean? 

• TRANSDERMAL (adjective)
  The adjective TRANSDERMAL has 1 sense:

1. through the unbroken skin; refers to medications applied directly to the skin (creams or ointments) or in time-release forms (skin patches)

  Familiarity information: TRANSDERMAL used as an adjective is very rare.

 Dictionary entry details 

• TRANSDERMAL (adjective)

Sense 1

Meaning:

Through the unbroken skin; refers to medications applied directly to the skin (creams or ointments) or in time-release forms (skin patches)

Classified under:

Relational adjectives (pertainyms)

Synonyms:

percutaneous; transcutaneous; transdermal; transdermic

Context example:

percutaneous absorption

Domain category:

materia medica; pharmacological medicine; pharmacology (the science or study of drugs: their preparation and properties and uses and effects)

Pertainym:

dermis (the deep vascular inner layer of the skin)

 Context examples 

Upon transdermal injection directly into the tumor, LTX315 may bind to the tumor cell membranes and subsequently lyse tumor cells, thereby inducing tumor cell necrosis.

(Lactoferrin-derived Lytic Peptide LTX-315, NCI Thesaurus)

A transdermal patch containing a 5 percent aqueous base solution of the synthetic amide-type anesthetic lidocaine with analgesic activity.

(Lidocaine Patch, NCI Thesaurus)

A transdermal matrix patch containing the synthetic opioid buprenorphine with analgesic and sedative activities.

(Buprenorphine Transdermal Matrix Patch, NCI Thesaurus)

A transdermal system containing granisetron, a selective serotonin (5-HT) receptor antagonist, with antiemetic activity.

(Granisetron Transdermal Patch, NCI Thesaurus)

A transdermal formulation containing the synthetic phenylpiperidine opioid agonist fentanyl, with analgesic activity.

(Fentanyl Matrix Transdermal Patch, NCI Thesaurus)

A sustained release transdermal patch containing the organic nitrate nitroglycerin, with vasodilator and potential immunomodulating activities.

(Nitroglycerin Transdermal Patch, NCI Thesaurus)

A transdermal patch containing the alkaloid nicotine with nicotine replacement activity.

(Nicotine patch, NCI Thesaurus)

Upon application of the transdermal patch to the skin and subsequent release into the bloodstream, granisetron selectively binds to and blocks the 5-HT subtype 3 (5-HT3) receptors located in the vagus nerve terminal and in the vomiting center in the central nervous system (CNS).

(Granisetron Transdermal Patch, NCI Thesaurus)

Upon topical administration, fentanyl diffuses from the transdermal patch through the skin, is transported via the systemic circulation, and selectively binds to the mu-receptor in the central nervous system (CNS), mimicking the effects of endogenous opiates.

(Fentanyl Matrix Transdermal Patch, NCI Thesaurus)

Upon topical application and transdermal delivery, the active ingredient lidocaine binds to and blocks voltage-gated sodium channels in the neuronal cell membrane; lidocaine-mediated stabilization of neuronal membranes inhibits the initiation and conduction of nerve impulses and produces a reversible local anesthesia.

(Lidocaine Patch, NCI Thesaurus)