TISSUE PLASMINOGEN ACTIVATOR

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does tissue plasminogen activator mean? 

• TISSUE PLASMINOGEN ACTIVATOR (noun)
  The noun TISSUE PLASMINOGEN ACTIVATOR has 1 sense:

1. a thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction

  Familiarity information: TISSUE PLASMINOGEN ACTIVATOR used as a noun is very rare.

 Dictionary entry details 

• TISSUE PLASMINOGEN ACTIVATOR (noun)

Sense 1

Meaning:

A thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction

Classified under:

Nouns denoting man-made objects

Synonyms:

Activase; tissue plasminogen activator

Hypernyms ("tissue plasminogen activator" is a kind of...):

clot buster; thrombolytic; thrombolytic agent (a kind of pharmaceutical that can break up clots blocking the flow of blood to the heart muscle)

 Context examples 

Synthesized and secreted locally from vascular endothelial cells; primary physiologic inhibitor of tissue plasminogen activator; also inhibits urokinase; implicated in thrombotic and hemorrhagic disorders.

(Plasminogen Activator Inhibitor, NIH CRISP Thesaurus)

A form of tissue plasminogen activator that is made in the laboratory.

(Activase, NCI Dictionary)

Also called Activase, r-tPA, and recombinant tissue plasminogen activator.

(Alteplase, NCI Dictionary)

Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption.

(Desmopressin, NCI Thesaurus)

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme.

(Alteplase, NCI Thesaurus)

Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis.

(Epiandrosterone, NCI Thesaurus)

As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation.

(Aprotinin, NCI Thesaurus)

Also called Alteplase, r-tPA, and recombinant tissue plasminogen activator.

(Activase, NCI Dictionary)