THIOGUANINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does thioguanine mean? 

• THIOGUANINE (noun)
  The noun THIOGUANINE has 1 sense:

1. an antineoplastic drug used to treat acute leukemias

  Familiarity information: THIOGUANINE used as a noun is very rare.

 Dictionary entry details 

• THIOGUANINE (noun)

Sense 1

Meaning:

An antineoplastic drug used to treat acute leukemias

Classified under:

Nouns denoting man-made objects

Hypernyms ("thioguanine" is a kind of...):

antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)

 Context examples 

A regimen consisting of daunorubicin, cytarabine (Ara-C) and thioguanine, used as an induction treatment for childhood acute myeloid leukemia (AML).

(DAT Regimen, NCI Thesaurus)

Two of those – ebselen and 6-thioguanine – were then found to both boost SUMOylation in rat cells and keep them alive in the absence of oxygen and glucose.

(Hibernating ground squirrels provide clues to new stroke treatments, National Institutes of Health)

A regimen consisting of cytarabine and thioguanine used as post remission maintenance treatment for acute myeloid leukemia.

(Cytarabine-Thioguanine Regimen, NCI Thesaurus)

After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication.

(Beta-Thioguanine Deoxyriboside, NCI Thesaurus)

An induction regimen consisting of dexamethasone, cytarabine, thioguanine, etoposide and idarubicin administered on an intensively-timed schedule as a form of timed-sequential therapy and used for the treatment of childhood acute myeloid leukemia.

(IDA-DCTER Regimen, NCI Thesaurus)

An induction regimen consisting of dexamethasone, cytarabine, thioguanine, etoposide and daunorubucin (or rubidomycin), administered on an intensively-timed schedule as a form of timed-sequential therapy and used for the treatment of childhood acute myeloid leukemia.

(DCTER Regimen, NCI Thesaurus)

A final experiment showed that ebselen boosted SUMOylation in the brains of healthy mice more than a control injection. 6-thioguanine was not tested because it is a chemotherapy drug with side effects that make it unsuitable as a potential stroke treatment.

(Hibernating ground squirrels provide clues to new stroke treatments, National Institutes of Health)