TELOMERE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does telomere mean? 

• TELOMERE (noun)
  The noun TELOMERE has 1 sense:

1. either (free) end of a eukaryotic chromosome

  Familiarity information: TELOMERE used as a noun is very rare.

 Dictionary entry details 

• TELOMERE (noun)

Sense 1

Meaning:

Either (free) end of a eukaryotic chromosome

Classified under:

Nouns denoting body parts

Context example:

telomeres act as caps to keep the sticky ends of chromosomes from randomly clumping together

Hypernyms ("telomere" is a kind of...):

end; terminal (either extremity of something that has length)

Holonyms ("telomere" is a part of...):

chromosome (a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order)

 Context examples 

This protein plays a role in the mediation of DNA double-strand break repair, recombination and telomere maintenance.

(Double-Strand Break Repair Protein MRE11A, NCI Thesaurus)

This protein plays a role in DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination.

(DNA Repair Protein RAD50, NCI Thesaurus)

Ku also binds to DNA ends with a telomere binding protein and mediates telomere capping to prevent fusion of chromosome ends and genetic instability.

(Ku Protein, NCI Thesaurus)

This allele, which encodes double-strand break repair protein MRE11A, is involved in the modulation of DNA recombination, telomere maintenance and double-strand break repair.

(MRE11A wt Allele, NCI Thesaurus)

Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes.

(Pancreatic Cancer Pathway, NCI Thesaurus/KEGG)

The resulting partially single-stranded telomere can adopt a circular confirmation.

(C-Circle, NCI Thesaurus)

Most telomeres are maintained by telomerase.

(Elongation by Telomerase, NCI Thesaurus)

As they erode over time, the chance of unravelling increases, so the length of telomeres can be used to estimate “biological age”.

(Breeder meerkats age faster, but their subordinates still die younger, University of Cambridge)

Tandem arrays of moderately repetitive (5-50 repeats) short (10-60 bases) DNA sequences found dispersed throughout the genome and clustered near telomeres.

(Minisatellite Repeat, NCI Thesaurus)

This process may be involved in lengthening telomeres and in resolving breaks induced by radiation, mutagenic chemicals and collapsed replication forks.

(Mitotic Recombination, NCI Thesaurus)