TELOMERASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does telomerase mean? 

• TELOMERASE (noun)
  The noun TELOMERASE has 1 sense:

1. an enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide

  Familiarity information: TELOMERASE used as a noun is very rare.

 Dictionary entry details 

• TELOMERASE (noun)

Sense 1

Meaning:

An enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide

Classified under:

Nouns denoting substances

Hypernyms ("telomerase" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

 Context examples 

A vaccine containing multiple peptides derived from the human telomerase reverse transcriptase (hTERT), survivin and cytomegalovirus (CMV), with potential immunostimulating and antineoplastic activities.

(hTERT/Survivin/CMV Multipeptide Vaccine, NCI Thesaurus)

Most telomeres are maintained by telomerase.

(Elongation by Telomerase, NCI Thesaurus)

A cancer vaccine directed against human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, with potential immunostimulating and antineoplastic activities.

(hTERT Vaccine V934/V935, NCI Thesaurus)

A cancer vaccine containing autologous dendritic cells (DCs) that are pulsed with mRNA encoding human telomerase reverse transcriptase (hTERT) and survivin peptide, with potential immunostimulatory and antineoplastic activities.

(hTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine, NCI Thesaurus)

PIN2/TERF1-interacting telomerase inhibitor 1 (328 aa, ~37 kDa) is encoded by the human PINX1 gene.

(PIN2/TERF1-Interacting Telomerase Inhibitor 1, NCI Thesaurus)

This allele, which encodes PIN2/TERF1-interacting telomerase inhibitor 1 protein, is involved in both the modulation of telomerase activity and chromosome segregation.

(PINX1 wt Allele, NCI Thesaurus)

This gene plays a role in both chromosome segregation and telomerase regulation.

(PINX1 Gene, NCI Thesaurus)

Directly linked to tumorigenesis, telomerase is expressed in the majority of human cancer cells but is infrequently expressed in normal cells.

(hTERT I540/R572Y/D988Y Multipeptide Vaccine, NCI Thesaurus)

Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells.

(FJ5002, NCI Thesaurus)

Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis.

(Imetelstat, NCI Thesaurus)