SUPPRESSOR GENE

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 Dictionary entry overview: What does suppressor gene mean? 

• SUPPRESSOR GENE (noun)
  The noun SUPPRESSOR GENE has 1 sense:

1. a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)

  Familiarity information: SUPPRESSOR GENE used as a noun is very rare.

 Dictionary entry details 

• SUPPRESSOR GENE (noun)

Sense 1

Meaning:

A gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)

Classified under:

Nouns denoting body parts

Synonyms:

suppresser; suppresser gene; suppressor; suppressor gene

Hypernyms ("suppressor gene" is a kind of...):

cistron; factor; gene ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity)

Hyponyms (each of the following is a kind of "suppressor gene"):

tumor suppressor gene (a suppressor gene that blocks unscheduled cell division)

 Context examples 

Hypomethylation in malignant cells may also restore suppressor gene expression and re-establish controlled growth and differentiation.

(DNA Methyltransferase Inhibitor, NCI Thesaurus)

Inappropriate gain of heterochromatin structure, such as the inactivation of tumor suppressor genes by DNA hyper-methylation at their promoter regions, can be directly linked to carcinogenesis.

(Epigenetic Silencing, NCI Thesaurus)

The allele is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

(CDKN2A wt Allele, NCI Thesaurus)

Therefore, this gene may be a myeloid leukemia tumor suppressor gene.

(JAW1-Related Protein, NCI Thesaurus)

Tumor suppressor genes located in the 18q21-qter region of human chromosome 18.

(DCC wt Allele, NLM, Medical Subject Headings)

Product of the p16 tumor suppressor gene, that acts as cyclin-dependent kinase inhibitor of CDK4.

(Cyclin-Dependent Kinase Inhibitor 2A, Isoform 4, NLM, Medical Subject Headings)

In addition, this gene is a candidate tumor suppressor gene for human breast cancer.

(FABP3 Gene, NCI Thesaurus)

This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis.

(Antineoplaston AS2-1, NCI Thesaurus)

A tumor suppressor gene that normally inhibits the growth of tumors.

(P53 gene, NCI Dictionary)

Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signaling pathway.

(Pancreatic Cancer Pathway, NCI Thesaurus/KEGG)