SUBSTRATE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does substrate mean? 

• SUBSTRATE (noun)
  The noun SUBSTRATE has 4 senses:

1. the substance that is acted upon by an enzyme or ferment

2. a surface on which an organism grows or is attached

3. any stratum or layer lying underneath another

4. an indigenous language that contributes features to the language of an invading people who impose their language on the indigenous population

  Familiarity information: SUBSTRATE used as a noun is uncommon.

 Dictionary entry details 

• SUBSTRATE (noun)

Sense 1

Meaning:

The substance that is acted upon by an enzyme or ferment

Classified under:

Nouns denoting substances

Hypernyms ("substrate" is a kind of...):

substance (the real physical matter of which a person or thing consists)

Sense 2

Meaning:

A surface on which an organism grows or is attached

Classified under:

Nouns denoting spatial position

Synonyms:

substrate; substratum

Context example:

the gardener talked about the proper substrate for acid-loving plants

Hypernyms ("substrate" is a kind of...):

surface (the extended two-dimensional outer boundary of a three-dimensional object)

Sense 3

Meaning:

Any stratum or layer lying underneath another

Classified under:

Nouns denoting spatial position

Synonyms:

substrate; substratum

Hypernyms ("substrate" is a kind of...):

stratum (one of several parallel layers of material arranged one on top of another (such as a layer of tissue or cells in an organism or a layer of sedimentary rock))

Sense 4

Meaning:

An indigenous language that contributes features to the language of an invading people who impose their language on the indigenous population

Classified under:

Nouns denoting communicative processes and contents

Synonyms:

substrate; substratum

Context example:

the Celtic languages of Britain are a substrate for English

Hypernyms ("substrate" is a kind of...):

indigenous language (a language that originated in a specified place and was not brought to that place from elsewhere)

 Context examples 

Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors.

(Oral Milataxel, NCI Thesaurus)

Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism.

(Akt inhibitor AZD5363, NCI Thesaurus)

This inhibits the formation of isoprenoids that are substrates for protein prenylation.

(Neridronic Acid, NCI Thesaurus)

Encoded by human NCK2 Gene, ubiquitous 380-aa 43-kDa cytoplasmic NCK Adaptor Protein 2, containing 1 SH2 domain and 3 SH3 domains, associates with tyrosine-phosphorylated growth factor receptors or their substrates.

(NCK Adaptor Protein 2, NCI Thesaurus)

An assay to determine the ability of cells to grow unattached to a substrate.

(Anchorage-Independent Growth, NCI Thesaurus)

This protein is involved in catalyzing the acetylation of protein substrates.

(N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit, NCI Thesaurus)

A type of culture in which cells grow as a monolayer that is attached to the culture substrate.

(Adherent Culture, NCI Thesaurus)

This allele, which encodes proline-rich AKT1 substrate 1 protein, is involved in the mTOR signaling pathway.

(AKT1S1 wt Allele, NCI Thesaurus)

The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors.

(pan-PIM Kinase Inhibitor AZD1208, NCI Thesaurus)

A class of enzymes that catalyze the removal of phosphate groups from their substrates.

(Phosphatase, NCI Thesaurus)