SUBSTANTIALLY

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does substantially mean? 

• SUBSTANTIALLY (adverb)
  The adverb SUBSTANTIALLY has 2 senses:

1. to a great extent or degree

2. in a strong substantial way

  Familiarity information: SUBSTANTIALLY used as an adverb is rare.

 Dictionary entry details 

• SUBSTANTIALLY (adverb)

Sense 1

Meaning:

To a great extent or degree

Synonyms:

considerably; substantially; well

Context example:

the price went up substantially

Pertainym:

substantial (of considerable importance, size, or worth)

Sense 2

Meaning:

In a strong substantial way

Context example:

the house was substantially built

Pertainym:

substantial (of good quality and condition; solidly built)

 Context examples 

More than 50% of adults in the United States take nutritional supplements and use of vitamin D has increased substantially over the last 20 years.

(Vitamin D does not prevent type 2 diabetes in people at high risk, National Institutes of Health)

However, unless Makemake is in a special orientation, these dark patches should make the dwarf planet’s brightness vary substantially as it rotates.

(Hubble Discovers Moon Orbiting the Dwarf Planet Makemake, NASA)

The researchers found that the 3 microbiota groups had substantially different risks for allergen sensitivity.

(Infant gut microbes linked to allergy, asthma risk, NIH)

But after the 2060s, river flows will substantially plunge.

(Bulk of Himalayan glaciers could vanish by 2100, SciDev.Net)

We know that individuals' responses to vaccination vary greatly and that the protection provided differs substantially between people.

(Gut Bacteria from Breastfeeding Linked to Improved Infant Response to Vaccines, U.S. Department of Agriculture)

This technique has found the most distant known exoplanets from Earth, and can detect low-mass planets that are substantially farther from their stars than Earth is from our sun.

('Iceball' Planet Discovered Through Microlensing, NASA)

This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors.

(HDAC Inhibitor CHR-3996, NCI Thesaurus)

The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits.

(BARD1 Pathway, NCI Thesaurus/BIOCARTA)

A new study now suggests that life as we know it is more unusual than previously thought because the universe substantially lacks phosphorus.

(Finding Alien Life Unlikely Due to Lack of Phosphorus in Universe, The Titi Tudorancea Bulletin)

Like other proteins involved in neurological diseases, tau protein clusters can seed themselves and contribute substantially to the disease processes of Alzheimer’s and CTE.

(New test detects protein associated with Alzheimer’s and CTE, National Institutes of Health)