SUBSTANTIA NIGRA

Pronunciation (US):

(GB):

 Dictionary entry overview: What does substantia nigra mean? 

• SUBSTANTIA NIGRA (noun)
  The noun SUBSTANTIA NIGRA has 1 sense:

1. a layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease

  Familiarity information: SUBSTANTIA NIGRA used as a noun is very rare.

 Dictionary entry details 

• SUBSTANTIA NIGRA (noun)

Sense 1

Meaning:

A layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease

Classified under:

Nouns denoting body parts

Synonyms:

locus niger; nucleus niger; substantia nigra

Hypernyms ("substantia nigra" is a kind of...):

neural structure (a structure that is part of the nervous system)

Holonyms ("substantia nigra" is a part of...):

mesencephalon; midbrain (the middle portion of the brain)

 Context examples 

Their analysis focused on the substantia nigra, a brain structure where Parkinson’s disease kills neurons that use the chemical dopamine to communicate with other cells.

(Waterlogged brain region helps scientists gauge damage caused by Parkinson’s disease, National Institutes of Health)

A part of the substantia nigra.

(Pars Compacta, NCI Thesaurus)

The researchers also found that NM-MRI signal in the substantia nigra was associated with functional MRI measures of regional cerebral blood flow.

(Neuromelanin-sensitive MRI identified as a potential biomarker for psychosis, National Institutes of Health)

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra.

(Parkinson's Disease Pathway KEGG, NCI Thesaurus/KEGG)

A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus.

(Parkinson's Disease, NCI Thesaurus)

Clusters of neurons comprising the globus pallidus, putamen, caudate, nucleus accumbens, substantia nigra and subthalamic nucleus.

(Basal Ganglia, NCI Thesaurus)

The midbrain contains the cerebral peduncles, oculomotor, trochlear and red nuclei, substantia nigra and various other nuclei and tracts.

(Mesencephalon, NCI Thesaurus)

Parkinson’s disease is a degenerative disorder that attacks nerve cells in many parts of the nervous system, most notably in a brain region called the substantia nigra, which releases dopamine, a chemical messenger important for movement.

(Too much protein may kill brain cells as Parkinson’s progresses, NINDS)

Parkinson’s disease destroys dopamine-producing cells in the substantia nigra, which connect to adjacent brain areas.

(Waterlogged brain region helps scientists gauge damage caused by Parkinson’s disease, National Institutes of Health)

Neuromelanin is a dark pigment created within dopamine neurons of the midbrain — particularly in the substantia nigra, a brain area that plays a role in reward and movement.

(Neuromelanin-sensitive MRI identified as a potential biomarker for psychosis, National Institutes of Health)