SEVERE COMBINED IMMUNODEFICIENCY DISEASE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does severe combined immunodeficiency disease mean? 

• SEVERE COMBINED IMMUNODEFICIENCY DISEASE (noun)
  The noun SEVERE COMBINED IMMUNODEFICIENCY DISEASE has 1 sense:

1. a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

  Familiarity information: SEVERE COMBINED IMMUNODEFICIENCY DISEASE used as a noun is very rare.

 Dictionary entry details 

• SEVERE COMBINED IMMUNODEFICIENCY DISEASE (noun)

Sense 1

Meaning:

A congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life

Classified under:

Nouns denoting stable states of affairs

Synonyms:

SCID; severe combined immunodeficiency; severe combined immunodeficiency disease

Hypernyms ("severe combined immunodeficiency disease" is a kind of...):

immunodeficiency (immunological disorder in which some part of the body's immune system is inadequate and resistance to infectious diseases is reduced)

monogenic disease; monogenic disorder (an inherited disease controlled by a single pair of genes)

Hyponyms (each of the following is a kind of "severe combined immunodeficiency disease"):

ADA-SCID (SCID resulting from mutation of a gene that codes for adenosine deaminase)

X-linked SCID; X-SCID (SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor)

 Context examples 

Mutations in the JAK3 gene which abolish the tyrosine-protein kinase activity of its protein product cause autosomal severe combined immunodeficiency disease.

(JAK3 wt Allele, NCI Thesaurus)

Some humans with SCID (severe combined immunodeficiency disease) also have mutation of their IL-7 receptor gene leading to an absence of T cells and greatly impaired B cell production.

(IL7 Signaling Pathway, NCI Thesaurus/BIOCARTA)