SENESCENT

Pronunciation (US):

(GB):

 Dictionary entry overview: What does senescent mean? 

• SENESCENT (adjective)
  The adjective SENESCENT has 1 sense:

1. growing old

  Familiarity information: SENESCENT used as an adjective is very rare.

 Dictionary entry details 

• SENESCENT (adjective)

Sense 1

Meaning:

Growing old

Synonyms:

ageing; aging; senescent

Similar:

old ((used especially of persons) having lived for a relatively long time or attained a specific age)

Derivation:

senesce (grow old or older)

senescence (the property characteristic of old age)

senescence (the organic process of growing older and showing the effects of increasing age)

 Context examples 

Previous research showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life.

(Scientists Find Natural Product That Slows Aging, The Titi Tudorancea Bulletin)

In this study, the team used a combination of dasatinib and quercetin (D+Q) to test whether this senolytic combination could slow physical dysfunction caused by senescent cells.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

To determine whether senescent cells caused physical dysfunction, the researchers first injected young (four-month-old) mice with either senescent (SEN) cells or non-senescent control (CON) cells.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

Researchers didn't have a way to identify if a treatment was actually attacking the particular cells that are senescent, until now.

(Scientists Find Natural Product That Slows Aging, The Titi Tudorancea Bulletin)

Senolytics are a class of drugs which selectively eliminate senescent cells.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

Senescent cells increase in many tissues with aging; they also occur in organs associated with many chronic diseases and after radiation or chemotherapy.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

In addition to young mice injected with senescent cells, the researchers also tested older (20-month-old), non-transplanted mice with D+Q intermittently for 4 months.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

They found that D+Q selectively killed senescent cells and slowed the deterioration in walking speed, endurance, and grip strength in the SEN mice.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

In addition, the researchers saw increased numbers of senescent cells, beyond what was injected, suggesting a propagation of the senescence effect into neighboring cells.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

A research team led by James L. Kirkland, M.D., Ph.D., of the Mayo Clinic in Rochester, Minnesota found that injecting even a small number of senescent cells into young, healthy mice causes damage that can result in physical dysfunction.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)