SENESCENCE

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 Dictionary entry overview: What does senescence mean? 

• SENESCENCE (noun)
  The noun SENESCENCE has 2 senses:

1. the organic process of growing older and showing the effects of increasing age

2. the property characteristic of old age

  Familiarity information: SENESCENCE used as a noun is rare.

 Dictionary entry details 

• SENESCENCE (noun)

Sense 1

Meaning:

The organic process of growing older and showing the effects of increasing age

Classified under:

Nouns denoting natural processes

Synonyms:

ageing; aging; senescence

Hypernyms ("senescence" is a kind of...):

biological process; organic process (a process occurring in living organisms)

Hyponyms (each of the following is a kind of "senescence"):

catabiosis (normal aging of cells)

Derivation:

senescent (growing old)

Sense 2

Meaning:

The property characteristic of old age

Classified under:

Nouns denoting attributes of people and objects

Synonyms:

agedness; senescence

Hypernyms ("senescence" is a kind of...):

oldness (the opposite of youngness)

Derivation:

senescent (growing old)

 Context examples 

Many different stimuli exert checkpoint control including TGFb, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal.

(G1/S Checkpoint Pathway, NCI Thesaurus/BIOCARTA)

This induces cell cycle arrest, senescence and apoptosis in susceptible tumor cells. miR-34 is downregulated in most solid and hematologic malignancies and regulates the expression of a variety of genes.

(Liposome-encapsulated miR-34 Mimic MRX34, NCI Thesaurus)

Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.

(Bizelesin, NCI Thesaurus)

Atherosclerosis and hair greying share similar mechanisms such as impaired DNA repair, oxidative stress, inflammation, hormonal changes and senescence of functional cells.

(Grey Hair Linked with Increased Heart Disease Risk in Men, The Titi Tudorancea Bulletin)

This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis.

(p53 Signaling Pathway KEGG, NCI Thesaurus/KEGG)

In addition, the researchers saw increased numbers of senescent cells, beyond what was injected, suggesting a propagation of the senescence effect into neighboring cells.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)

When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence.

(Scientists Find Natural Product That Slows Aging, The Titi Tudorancea Bulletin)

They resemble the cancer cell of origin that has escaped senescence – the natural process of cell ageing and "death" which concludes a healthy cell life cycle.

(‘Energetic Cancer Cells’ May Be Origin of Cancer Spread, The Titi Tudorancea Bulletin)

P-p68 is overexpressed in various types of solid tumors but absent in normal tissues, and plays a role in tumor progression and metastasis. p21 is a potent cyclin-dependent kinase inhibitor which regulates cell cycle progression and mediates both growth arrest and cellular senescence.

(P-p68 Inhibitor RX-5902, NCI Thesaurus)

Cell senescence is a process in which cells lose function, including the ability to divide and replicate, but are resistant to cell death.

(Senolytic drugs reverse damage caused by senescent cells in mice, National Institutes of Health)