SECRETASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does secretase mean? 

• SECRETASE (noun)
  The noun SECRETASE has 1 sense:

1. a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)

  Familiarity information: SECRETASE used as a noun is very rare.

 Dictionary entry details 

• SECRETASE (noun)

Sense 1

Meaning:

A set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)

Classified under:

Nouns denoting substances

Hypernyms ("secretase" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

 Context examples 

It is a type of gamma-secretase inhibitor and a type of Notch signaling inhibitor.

(Gamma-Secretase Inhibitor RO4929097, NCI Dictionary)

An orally bioavailable, small-molecule gamma secretase (GS) inhibitorwith potential antitumor activity.

(Gamma-Secretase Inhibitor RO4929097, NCI Thesaurus)

Gamma secretase inhibitor PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch.

(Gamma Secretase Inhibitor PF-03084014, NCI Thesaurus)

Presenilin-1 is also a component in gamma-secretase activity involved in signaling by the transmembrane protein Notch.

(Notch and Wnt Signaling Pathway, NCI Thesaurus/BIOCARTA)

It has also been argued that the gamma secretase is not presenilin-1 itself, but another polypeptide that requires Notch for its activity and is distinct from Presenilin-1.

(Notch Proteolysis and Signaling Pathway, NCI Thesaurus/BIOCARTA)

Inhibition of the beta- or gamma-secretases may provide a mechanism to treat this disease.

(Amyloid Beta-Peptide Pathway, NCI Thesaurus/BIOCARTA)

Beta-secretase 2 (518 aa, ~56 kDa) is encoded by the human BACE2 gene.

(Beta-Secretase 2, NCI Thesaurus)

This allele, which encodes beta-secretase 2 protein, plays a role in protein cleavage.

(BACE2 wt Allele, NCI Thesaurus)

Beta-secretase 1 (501 aa, ~56 kDa) is encoded by the human BACE1 gene.

(Beta-Secretase 1, NCI Thesaurus)

The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which is a product of regulated intramembrane proteolysis mediated by the gamma-secretase enzyme complex.

(Notch Receptor Intracellular Domain, NCI Thesaurus)