SCRAPIE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does scrapie mean? 

• SCRAPIE (noun)
  The noun SCRAPIE has 1 sense:

1. a fatal disease of sheep characterized by chronic itching and loss of muscular control and progressive degeneration of the central nervous system

  Familiarity information: SCRAPIE used as a noun is very rare.

 Dictionary entry details 

• SCRAPIE (noun)

Sense 1

Meaning:

A fatal disease of sheep characterized by chronic itching and loss of muscular control and progressive degeneration of the central nervous system

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("scrapie" is a kind of...):

animal disease (a disease that typically does not affect human beings)

 Context examples 

In the Broad Institute experiments, mice received either ASO1 or ASO2 2 weeks before infection with scrapie and then seven weeks after infection.

(Experimental treatment slows prion disease, extends life of mice, National Institutes of Health)

Other prion diseases include scrapie in sheep and bovine spongiform encephalopathy, or mad cow disease, in cattle.

(Study finds no chronic wasting disease transmissibility in macaques, National Institutes of Health)

In the studies, scientists injected ASOs into the spinal fluid of mice already infected with scrapie or that were challenged with scrapie proteins within weeks of the injection.

(Experimental treatment slows prion disease, extends life of mice, National Institutes of Health)

The RML group also tested the ASOs against established prion disease, treating mice 17 weeks after they were infected with scrapie – near the onset of clinical signs.

(Experimental treatment slows prion disease, extends life of mice, National Institutes of Health)

Scrapie, which affects sheep and goats and can be adapted to rodents, is closely related to human prion diseases such as Creutzfeldt-Jakob disease, which is currently untreatable.

(Experimental treatment slows prion disease, extends life of mice, National Institutes of Health)

RML scientists injected either ASO1 or ASO2 into mice 14 days prior to infecting them with scrapie, and then seven or 15 weeks after infection.

(Experimental treatment slows prion disease, extends life of mice, National Institutes of Health)

Thus, scrapie is a valuable experimental model for the development of human prion disease therapies.

(Experimental treatment slows prion disease, extends life of mice, National Institutes of Health)

Scientists using an experimental treatment have slowed the progression of scrapie, a degenerative central nervous disease caused by prions, in laboratory mice and greatly extended the rodents’ lives.

(Experimental treatment slows prion disease, extends life of mice, National Institutes of Health)