SARCOMERE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does sarcomere mean? 

• SARCOMERE (noun)
  The noun SARCOMERE has 1 sense:

1. one of the segments into which a myofibril is divided

  Familiarity information: SARCOMERE used as a noun is very rare.

 Dictionary entry details 

• SARCOMERE (noun)

Sense 1

Meaning:

One of the segments into which a myofibril is divided

Classified under:

Nouns denoting body parts

Hypernyms ("sarcomere" is a kind of...):

segment (one of the parts into which something naturally divides)

Holonyms ("sarcomere" is a part of...):

myofibril; myofibrilla; sarcostyle (one of many contractile filaments that make up a striated muscle fiber)

 Context examples 

Hundreds of mutations in 11 genes that encode protein constituents of the sarcomere have been identified in HCM.

(Hypertrophic Cardiomyopathy Pathway, NCI Thesaurus/KEGG)

Each individual heart cell, known as a cardiomyocyte, contains contractile units called sarcomeres that power its beating.

(Microtubules’ role in heart cell contraction revealed, NIH)

They anchor actin filaments from terminal sarcomeres and transmit contractile force between myocytes.

(Fascia Adherens, NCI Thesaurus)

Hypertrophic cardiomyopathy caused by mutations in the genes encoding components of the sarcomere, in the absence of predisposing conditions.

(Familial Hypertrophic Cardiomyopathy, NCI Thesaurus)

It has been widely proposed that left ventricular hypertrophy is not a primary manifestation but develops as compensatory response to sarcomere dysfunction.

(Hypertrophic Cardiomyopathy Pathway, NCI Thesaurus/KEGG)

The scientists found that MTs are linked to sarcomeres through a lattice-like structure.

(Microtubules’ role in heart cell contraction revealed, NIH)

They noted that as the cells contracted, the MTs “buckled” under the force in a pattern that coincided with contraction of the sarcomeres.

(Microtubules’ role in heart cell contraction revealed, NIH)

When tyrosine was removed from MTs by a natural process called detyrosination, the MTs formed tighter, stiffer connections with the sarcomeres and restricted contraction.

(Microtubules’ role in heart cell contraction revealed, NIH)