REVERSE TRANSCRIPTASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does reverse transcriptase mean? 

• REVERSE TRANSCRIPTASE (noun)
  The noun REVERSE TRANSCRIPTASE has 1 sense:

1. a polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses

  Familiarity information: REVERSE TRANSCRIPTASE used as a noun is very rare.

 Dictionary entry details 

• REVERSE TRANSCRIPTASE (noun)

Sense 1

Meaning:

A polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses

Classified under:

Nouns denoting substances

Hypernyms ("reverse transcriptase" is a kind of...):

polymerase (an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA)

 Context examples 

A viral reverse transcriptase is bound to the 5' extremity of the long strand.

(hepatitis B virus, NCI Thesaurus)

A dideoxyuridine inhibitor of HIV reverse transcriptase that is related to zidovudine.

(Navuridine, NCI Thesaurus)

A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

(Efavirenz, NCI Thesaurus)

A diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.

(Dapivirine, NCI Thesaurus)

Methods for building collections of cloned DNA consisting of DNA copies of all the mRNAs produced by a cell type. cDNAs are generated using reverse transcriptase and either an oligo-dT or random primer.

(cDNA Library Construction, NCI Thesaurus)

The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase).

(Clevudine, NCI Thesaurus)

A nucleoside reverse transcriptase inhibitor analog of adenosine.

(Didanosine, NCI Thesaurus)

Emivirine has a structure typical of a nucleoside analog but has been shown to bind directly to the reverse transcriptase and act as an NNRTI.

(Emivirine, NCI Thesaurus)

It can bind the enzyme reverse transcriptase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT.

(Etravirine, NCI Thesaurus)

Single-stranded DNA that is complementary to messenger RNA or DNA that has been synthesized from messenger RNA by reverse transcriptase.

(cDNA, NCI Thesaurus)