RETINOBLASTOMA

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does retinoblastoma mean? 

• RETINOBLASTOMA (noun)
  The noun RETINOBLASTOMA has 1 sense:

1. malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells

  Familiarity information: RETINOBLASTOMA used as a noun is very rare.

 Dictionary entry details 

• RETINOBLASTOMA (noun)

Sense 1

Meaning:

Malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("retinoblastoma" is a kind of...):

malignant neoplasm; malignant tumor; metastatic tumor (a tumor that is malignant and tends to spread to other parts of the body)

 Context examples 

A retinoblastoma with well differentiated features.

(Differentiated Retinoblastoma, NCI Thesaurus)

Chemotherapy given to shrink a retinoblastoma tumor before treatment with radiation or surgery.

(Chemoreduction, NCI Dictionary)

Retinoblastoma that has spread beyond the eye e.g. to brain, soft tissue/bone, bone marrow.

(Extraocular Retinoblastoma, NCI Thesaurus)

P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found.

(HeLa, NCI Thesaurus)

The gene is expressed at elevated levels in neuroblastoma, retinoblastoma, small cell lung carcinoma and astrocytoma.

(MYCN wt Allele, NCI Thesaurus)

HPV E7 oncogenic protein binds the retinoblastoma tumor suppressor protein, pRB, as well as a number of other cellular proteins, and serves as a transcriptional activator.

(Human Papillomavirus 16 E7 Peptide/Padre 965.10, NCI Thesaurus)

By inhibiting CDK activity, R547 also reduces phosphorylation of the retinoblastoma (Rb) protein, thereby preventing activation of transcription factor E2F and leading to further suppression of tumor cell proliferation.

(CDKI R547, NCI Thesaurus)

This agent has also been shown to inhibit the growth of retinoblastomas, and may exhibit some antiproliferative activity against prostate cancer cells.

(Doxercalciferol, NCI Thesaurus)

Variant alleles are associated with several types of cancers; including, retinoblastoma, mesenchymal tumors and ductal carcinoma.

(BRCD1 wt Allele, NCI Thesaurus)

This gene plays a role in tumor suppression and is frequently associated with retinoblastoma and ductal carcinoma.

(BRCD1 Gene, NCI Thesaurus)