RB

Pronunciation (US):

(GB):

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 Dictionary entry overview: What does Rb mean? 

• RB (noun)
  The noun RB has 1 sense:

1. a soft silvery metallic element of the alkali metal group; burns in air and reacts violently in water; occurs in carnallite and lepidolite and pollucite

  Familiarity information: RB used as a noun is very rare.

 Dictionary entry details 

• RB (noun)

Sense 1

Meaning:

A soft silvery metallic element of the alkali metal group; burns in air and reacts violently in water; occurs in carnallite and lepidolite and pollucite

Classified under:

Nouns denoting substances

Synonyms:

atomic number 37; Rb; rubidium

Hypernyms ("Rb" is a kind of...):

metal; metallic element (any of several chemical elements that are usually shiny solids that conduct heat or electricity and can be formed into sheets etc.)

Holonyms ("Rb" is a substance of...):

carnallite (a white or reddish mineral consisting of hydrous chlorides of potassium and magnesium; used as a fertilizer and as a source of potassium and magnesium)

lepidolite (a mineral of the mica group; an important source of lithium)

pollucite (a rare mineral that is an important source of cesium)

 Context examples 

When dephosphorylated in G1, Rb complexes with and blocks transcriptional activation by E2F transcription factors.

(Cyclin E Degradation Pathway, NCI Thesaurus/BIOCARTA)

Another target of prolonged p38 activation during infection is Rb, contributing to viral replication.

(Human Cytomegalovirus Infection Pathway, NCI Thesaurus/BIOCARTA)

CGTG-102 is designed to replicate only in cells with defects in the p16/Rb/E2F pathway, attributed to a mutation common in many solid tumors.

(GM-CSF-encoding Oncolytic Adenovirus CGTG-102, NCI Thesaurus)

Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest.

(Palbociclib, NCI Thesaurus)

As most tumor cells are defective in the Rb/p16 pathway, this virus selectively replicates in these cells.

(Conditionally Replicative Adenovirus 5/3-delta24, NCI Thesaurus)

CDK4/6 inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1.

(CDK4/6 Dual Inhibitor LY2835219, NCI Thesaurus)

Complexes with and inactivates Rb protein resulting in disruption of cell cycle regulation.

(Papillomavirus Transforming Protein E7, NCI Thesaurus)

CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation.

(CDK4/6 Inhibitor LEE011, NCI Thesaurus)

Downstream targets of CDKs include transcription factor E2F and its regulator Rb.

(Cell Cycle Pathway, NCI Thesaurus/KEGG)

By inhibiting CDK activity, R547 also reduces phosphorylation of the retinoblastoma (Rb) protein, thereby preventing activation of transcription factor E2F and leading to further suppression of tumor cell proliferation.

(CDKI R547, NCI Thesaurus)