RAS

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does RAS mean? 

• RAS (noun)
  The noun RAS has 1 sense:

1. the network in the reticular formation that serves an alerting or arousal function

  Familiarity information: RAS used as a noun is very rare.

 Dictionary entry details 

• RAS (noun)

Sense 1

Meaning:

The network in the reticular formation that serves an alerting or arousal function

Classified under:

Nouns denoting body parts

Synonyms:

RAS; reticular activating system

Hypernyms ("RAS" is a kind of...):

neural net; neural network (any network of neurons or nuclei that function together to perform some function in the body)

Holonyms ("RAS" is a part of...):

reticular formation; RF (a complex neural network in the central core of the brainstem; monitors the state of the body and functions in such processes as arousal and sleep and attention and muscle tone)

 Context examples 

The EGF receptor activates ras and the MAP kinase pathway, ultimately causing phosphorylation of transcription factors such as c-Fos to create AP-1 and ELK-1 that contribute to proliferation.

(EGF Signaling Pathway, NCI Thesaurus/BIOCARTA)

Encoded by human FRS3 Gene, 492-aa 54-kDa plasma membrane-associated FGFR Substrate 3 is an FGFR substrate that links FGFR stimulation to RAS activators.

(FGFR Substrate 3, NCI Thesaurus)

D4-GDP dissociation inhibitor (D4-GDI) is a negative regulator of the ras related Rho Family of GTPases.

(D4-GDI Signaling Pathway, NCI Thesaurus/BIOCARTA)

As a GPCR, CXCR4 binding of SDF-1 activates G-protein mediated signaling, including downstream pathways such as ras, and PI3 kinase.

(CXCR4 Signaling Pathway, NCI Thesaurus/BIOCARTA)

A quinolinone derivative that inhibits farnesyl protein transferase, an enzyme that mediates the farnesylation of RAS, causing possible inhibition of the RAS pathway.

(CP-609,754, NCI Thesaurus)

More than 30 percent of all human cancers are driven by mutations in a family of genes known collectively as RAS, which has three members: KRAS, NRAS, and HRAS.

(Cellular immunotherapy targets a common human cancer mutation, NIH)

Ras regulates cyclin D1 expression to affect the G1 to S transition.

(G1 to S Transition Pathway, NCI Thesaurus/BIOCARTA)

Therefore, loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect.

(Non-Small Cell Lung Cancer Pathway, NCI Thesaurus/KEGG)

Implicated in a variety of human tumors, mutations of specific amino acids activate RAS to transform cells.

(Oncogene K-Ras, NCI Thesaurus)

SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway.

(Neuronal SHC, NCI Thesaurus)