PT

Pronunciation (US):

(GB):

 Dictionary entry overview: What does Pt mean? 

• PT (noun)
  The noun PT has 1 sense:

1. a heavy precious metallic element; grey-white and resistant to corroding; occurs in some nickel and copper ores and is also found native in some deposits

  Familiarity information: PT used as a noun is very rare.

 Dictionary entry details 

• PT (noun)

Sense 1

Meaning:

A heavy precious metallic element; grey-white and resistant to corroding; occurs in some nickel and copper ores and is also found native in some deposits

Classified under:

Nouns denoting substances

Synonyms:

atomic number 78; platinum; Pt

Hypernyms ("Pt" is a kind of...):

noble metal (any metal that is resistant to corrosion or oxidation)

 Context examples 

Circulating anti-neuronal antibodies (anti-Hu; also called ANNA 1) and small cell lung carcinomas are frequently associated with this condition. (From Pathologe 1997 Sep;18(5):406-10; J Int Neuropsychol Soc 1996 Sep;2(5):460-6; Brain 1997 Jun;120(Pt 6):923-8)

(Limbic Encephalitis, NLM, Medical Subject Headings)

Polymeric micellar nanoparticles containing diaminocyclohexane platinum (DACH-platin or DACH-Pt) with potential antineoplastic activity.

(DACH-Platin Micelle NC-4016, NCI Thesaurus)

This polymer drug delivery system consists of cytotoxic diaminocyclohexane (DACH)-platinum (Pt) coupled to a water-soluble biocompatible hydroxypropylmethacrylamide (HPMA) copolymer via a pH sensitive linker.

(DACH Polymer Platinate AP5346, NCI Thesaurus)

An element with atomic symbol Pt, atomic number 78, and atomic weight 195.09.

(Platinum, NCI Thesaurus)

G Protein-Coupled Receptor Kinase-Interactor 1: GIT1 is a multidomain protein that is thought to function as an integrator of signaling pathways controlling vesicle trafficking, adhesion and cytoskeletal organization. (from J Cell Sci 2002 Apr 1;115(Pt 7):1497-510)

(G Protein-Coupled Receptor Kinase-Interactor 1, NCI Thesaurus)

Due to decreased pH at the tumor site, the linker is cleaved and the chelated active moiety DACH-Pt is released in tumor cells.

(DACH Polymer Platinate AP5346, NCI Thesaurus)

DACH-Pt alkylates macromolecules and causes both inter- and intra-strand platinum-DNA crosslinks, which impede DNA replication and transcription, thereby resulting in cell-cycle independent cytotoxicity.

(DACH Polymer Platinate AP5346, NCI Thesaurus)

The HPMA-based drug delivery system enhances the concentration of DACH-Pt at the tumor site and prolongs the half life of the agent, thereby increasing exposure and efficacy at the target tumor sites while minimizing side effects in normal tissues.

(DACH Polymer Platinate AP5346, NCI Thesaurus)