PROTHROMBIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does prothrombin mean? 

• PROTHROMBIN (noun)
  The noun PROTHROMBIN has 1 sense:

1. a protein in blood plasma that is the inactive precursor of thrombin

  Familiarity information: PROTHROMBIN used as a noun is very rare.

 Dictionary entry details 

• PROTHROMBIN (noun)

Sense 1

Meaning:

A protein in blood plasma that is the inactive precursor of thrombin

Classified under:

Nouns denoting substances

Synonyms:

factor II; prothrombin

Hypernyms ("prothrombin" is a kind of...):

clotting factor; coagulation factor (any of the factors in the blood whose actions are essential for blood coagulation)

 Context examples 

A laboratory test result which indicates increased ratio of the patient's prothrombin time to a control sample in the blood.

(INR Increased, NCI Thesaurus)

Absence or reduced levels of prothrombin in the blood.

(Hereditary Factor II Deficiency, NLM, Medical Subject Headings)

This allele, which encodes prothrombin protein, is involved in the regulation of coagulation.

(F2 wt Allele, NCI Thesaurus)

Multiple heterodimeric alpha/beta combinations result in different integrins. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor.

(Integrin AlphaV/Beta3, NCI Thesaurus)

The intrinsic mechanism of prothrombin activator formation begins with trauma to the blood or exposure of blood to collagen in a traumatized vessel wall.

(Intrinsic Prothrombin Activation Pathway, NCI Thesaurus/BIOCARTA)

It is also involved in the biosynthesis of prothrombin.

(NQO1 wt Allele, NCI Thesaurus)

Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT).

(Lepirudin, NCI Thesaurus)

The two peptides that can be released by proteolytic activation of prothrombin to thrombin.

(F1.2, NCI Thesaurus)

A very rare autosomal recessive inherited blood coagulation disorder characterized by deficiency of prothrombin, resulting in bleeding.

(Hereditary Factor II Deficiency, NCI Thesaurus)

The first phase is the activation of a prothrombin activator complex.

(Extrinsic Prothrombin Activation Pathway, NCI Thesaurus/BIOCARTA)