PROTEOLYTIC

Pronunciation (US):

(GB):

 Dictionary entry overview: What does proteolytic mean? 

• PROTEOLYTIC (adjective)
  The adjective PROTEOLYTIC has 1 sense:

1. of or relating to proteolysis

  Familiarity information: PROTEOLYTIC used as an adjective is very rare.

 Dictionary entry details 

• PROTEOLYTIC (adjective)

Sense 1

Meaning:

Of or relating to proteolysis

Classified under:

Relational adjectives (pertainyms)

Pertainym:

proteolysis (the hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds)

Derivation:

proteolysis (the hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds)

 Context examples 

After internalization and proteolytic cleavage, SN-38 selectively stabilizes topoisomerase I-DNA covalent complexes, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis.

(Anti-TROP-2 Antibody-Drug Conjugate IMMU-132, NCI Thesaurus)

Phosphorylation of Beta-catenin induces the ubiquitination and proteolytic degradation of beta-catenin by the proteasome.

(Notch and Wnt Signaling Pathway, NCI Thesaurus/BIOCARTA)

They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes.

(Bone Morphogenetic Protein, NLM, Medical Subject Headings)

The PEG moiety inhibits proteolytic breakdown and clearance of AM0010, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing.

(Pegylated Recombinant Human Interleukin-10 AM0010, NCI Thesaurus)

Upon intravenous administration of ADC AGS-16C3F, the monoclonal antibody moiety of this conjugate selectively binds to ENPP3 then is internalized and undergoes proteolytic cleavage to release MMAF.

(Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F, NCI Thesaurus)

The PEG moiety inhibits proteolytic breakdown and clearance of IFN-a2b, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing.

(PEG-Proline-Interferon Alfa-2b, NCI Thesaurus)

Three different proteolytic steps process the 300 kD precursor of mature Notch.

(Notch Proteolysis and Signaling Pathway, NCI Thesaurus/BIOCARTA)

Endostatin, a 20 kDa C-terminal proteolytic fragment of collagen XVIII, is an important angiogenesis inhibitor.

(Adenovirus Encoding Recombinant Human Endostatin, NCI Thesaurus)

This allele, which encodes beta-secretase 1 protein, is involved in proteolytic processing.

(BACE1 wt Allele, NCI Thesaurus)

Phosphorylation of p27 at threonine-187 by cdk2 causes p27 to associate with an SCF complex that targets p27 for proteolytic degradation.

(p27 Regulation Pathway, NCI Thesaurus/BIOCARTA)