PROTEASE INHIBITOR

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does protease inhibitor mean? 

• PROTEASE INHIBITOR (noun)
  The noun PROTEASE INHIBITOR has 1 sense:

1. an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs

  Familiarity information: PROTEASE INHIBITOR used as a noun is very rare.

 Dictionary entry details 

• PROTEASE INHIBITOR (noun)

Sense 1

Meaning:

An antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs

Classified under:

Nouns denoting man-made objects

Synonyms:

PI; protease inhibitor

Hypernyms ("protease inhibitor" is a kind of...):

antiviral; antiviral agent; antiviral drug (any drug that destroys viruses)

Hyponyms (each of the following is a kind of "protease inhibitor"):

Crixivan; indinavir (a protease inhibitor (trade name Crixivan) used for treating HIV)

nelfinavir; Viracept (a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs)

Norvir; ritonavir (a protease inhibitor (trade name Norvir) used in treating HIV)

Invirase; saquinavir (a weak protease inhibitor (trade name Invirase) used in treating HIV)

Holonyms ("protease inhibitor" is a part of...):

drug cocktail; HAART; highly active antiretroviral therapy (a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV)

 Context examples 

It is a type of protease inhibitor.

(BBIC, NCI Dictionary)

Atazanavir does not elevate serum lipids, a common problem with other protease inhibitors.

(Atazanavir, NCI Thesaurus)

Kunitz-type protease inhibitor 1 (529 aa, ~58 kDa) is encoded by the human SPINT1 gene.

(Kunitz-Type Protease Inhibitor 1, NCI Thesaurus)

Many members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity.

(Kininogen Family Gene, NCI Thesaurus)

Kaletra is a type of anti-HIV agent and a type of protease inhibitor.

(Kaletra, NCI Dictionary)

A protease inhibitor that is designed to target the human immunodeficiency virus (HIV) protease while sparing other host cell proteases.

(HIV Protease Inhibitor, NCI Thesaurus)

It is a type of anti-HIV agent and a type of protease inhibitor.

(Aptivus, NCI Dictionary)

The ritonavir in the combination drug increases the concentration and biological half-life of lopinavir but is not present in sufficient concentration to act as a protease inhibitor.

(Lopinavir/ritonavir, NCI Thesaurus)

In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily.

(Alpha-1-Proteinase Inhibitor Human, NCI Thesaurus)

A peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation.

(Lopinavir, NCI Thesaurus)