PROINFLAMMATORY

Pronunciation (US):

(GB):

 Dictionary entry overview: What does proinflammatory mean? 

• PROINFLAMMATORY (adjective)
  The adjective PROINFLAMMATORY has 1 sense:

1. tending to cause inflammation

  Familiarity information: PROINFLAMMATORY used as an adjective is very rare.

 Dictionary entry details 

• PROINFLAMMATORY (adjective)

Sense 1

Meaning:

Tending to cause inflammation

Synonyms:

pro-inflammatory; proinflammatory

Similar:

unhealthy (not in or exhibiting good health in body or mind)

 Context examples 

A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha), with anti-inflammatory activity.

(Certolizumab, NCI Thesaurus)

IL-1b, a proinflammatory cytokine, plays a key role in inflammation.

(Canakinumab, NCI Thesaurus)

Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pressure regulating peptide angiotensin.

(Bioactive Peptide Signaling Pathway, NCI Thesaurus/BIOCARTA)

CC-11006 appears to have a similar mechanism to thalidomide and may modulate the expression of proinflammatory and regulatory cytokines.

(Immunomodulatory Agent CC-11006, NCI Thesaurus)

IL-10 apparently acts to repress secretion of proinflammatory cytokines.

(Cytokine Network Pathway, NCI Thesaurus/BIOCARTA)

By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth.

(I Kappa B, NCI Thesaurus)

The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB.

(Delanzomib, NCI Thesaurus)

IL-12 is a proinflammatory cytokine with numerous immunoregulatory functions and may augment host immune responses to tumor cells.

(Immunocytokine NHS-IL12, NCI Thesaurus)

After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.

(Beclomethasone, NCI Thesaurus)

Interleukin-17, encoded by the IL17 gene, is a proinflammatory cytokine produced by activated T cells.

(Interleukin-17, NCI Thesaurus/LocusLink)