PROGRAMMED CELL DEATH

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 Dictionary entry overview: What does programmed cell death mean? 

• PROGRAMMED CELL DEATH (noun)
  The noun PROGRAMMED CELL DEATH has 1 sense:

1. a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival

  Familiarity information: PROGRAMMED CELL DEATH used as a noun is very rare.

 Dictionary entry details 

• PROGRAMMED CELL DEATH (noun)

Sense 1

Meaning:

A type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival

Classified under:

Nouns denoting natural phenomena

Synonyms:

apoptosis; caspase-mediated cell death; programmed cell death

Hypernyms ("programmed cell death" is a kind of...):

cell death; necrobiosis ((physiology) the normal degeneration and death of living cells (as in various epithelial cells))

 Context examples 

This allele, which encodes programmed cell death protein 1, plays a role in the modulation of both apoptosis and cellular immunity.

(PDCD1 wt Allele, NCI Thesaurus)

A humanized monoclonal IgG4 antibody directed against human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1) with potential immunopotentiating activity.

(Lambrolizumab, NCI Thesaurus)

This allele, which encodes programmed cell death 1 ligand 2 protein, plays a role in the regulation of T-cell proliferation and cytokine expression.

(PDCD1LG2 wt Allele, NCI Thesaurus)

A fully human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1/PCD-1) with immunopotentiation activity.

(Nivolumab, NCI Thesaurus)

This allele, which encodes programmed cell death protein 4, may play a role in the modulation of both translation and apoptosis.

(PDCD4 wt Allele, NCI Thesaurus)

A humanized monoclonal antibody directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities.

(Pidilizumab, NCI Thesaurus)

This allele, which encodes tumor necrosis factor receptor superfamily member 6 protein, plays a role in the initiation of the caspase processing cascade that leads to programmed cell death.

(FAS wt Allele, NCI Thesaurus)

A biological process that selectively removes autoantigenic lymphocytes by targeting them for programmed cell death.

(Clonal Regression, NCI Thesaurus)

Independent of RAR activation, this agent also modulates gene expression that leads to ceramide-induced, caspase-independent programmed cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species (ROS).

(Fenretinide Lipid Matrix, NCI Thesaurus)

GDNF can rescue motor neurons from programmed cell death and death caused by axotomy.

(Glial Cell Line Derived Neurotrophic Factor, NCI Thesaurus/LocusLink)