PRECLUDE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does preclude mean? 

• PRECLUDE (verb)
  The verb PRECLUDE has 2 senses:

1. keep from happening or arising; make impossible

2. make impossible, especially beforehand

  Familiarity information: PRECLUDE used as a verb is rare.

 Dictionary entry details 

• PRECLUDE (verb)

Present simple: I / you / we / they preclude    ... he / she / it precludes   
Past simple: precluded   
Past participle: precluded   
-ing form: precluding   

Sense 1

Meaning:

Keep from happening or arising; make impossible

Classified under:

Verbs of political and social activities and events

Synonyms:

forbid; foreclose; forestall; preclude; prevent

Context example:

Your role in the projects precludes your involvement in the competitive project

Troponyms (each of the following is one way to "preclude"):

inhibit (prohibit, forbid, or prevent from doing something)

make unnecessary; save (make unnecessary an expenditure or effort)

avert; avoid; debar; deflect; fend off; forefend; forfend; head off; obviate; stave off; ward off (prevent the occurrence of; prevent from happening)

block; blockade; embarrass; hinder; obstruct; stymie; stymy (hinder or prevent the progress or accomplishment of)

baffle; bilk; cross; foil; frustrate; queer; scotch; spoil; thwart (hinder or prevent (the efforts, plans, or desires) of)

block; halt; kibosh; stop (stop from happening or developing)

Sentence frames:

Somebody ----s something
Something ----s something

Derivation:

preclusion (the act of preventing something by anticipating and disposing of it effectively)

Sense 2

Meaning:

Make impossible, especially beforehand

Classified under:

Verbs of being, having, spatial relations

Synonyms:

close out; preclude; rule out

Hypernyms (to "preclude" is one way to...):

eliminate; obviate; rid of (do away with)

Sentence frame:

Something ----s something

Derivation:

preclusive (made impossible)

 Context examples 

An union of a different tendency, and precluding the possibility of the other, was soon to be formed in their family.

(Pride and Prejudice, by Jane Austen)

NOTE(S): Deviations usually do not preclude the overall evaluability of subject data for either efficacy or safety.

(Performed Protocol Deviation, NCI Thesaurus/BRIDG)

Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent.

(Cerivastatin, NCI Thesaurus)

Its presence does not indicate disease progession but precludes a determination of complete remission based on the modified overall immune related response criteria.

(Modified Overall Immune Related Response Criterion, New Non-Measurable Lesion, NCI Thesaurus)

In addition, the exclusion of polysorbate 80 in this formulation precludes foaming during the preparation process, thus facilitating preparation and administration.

(Docetaxel Emulsion ANX-514, NCI Thesaurus)

We have a story of a flight and a descent by ropes which precluded the production of larger specimens.

(The Lost World, by Sir Arthur Conan Doyle)

Their homes were so distant, and the circles in which they moved so distinct, as almost to preclude the means of ever hearing of each other's existence during the eleven following years, or, at least, to make it very wonderful to Sir Thomas that Mrs. Norris should ever have it in her power to tell them, as she now and then did, in an angry voice, that Fanny had got another child.

(Mansfield Park, by Jane Austen)

“I rather hope to satisfy you both,” said Emma, “for I shall do all in my power to make them happy, which will be enough for Isabella; and happiness must preclude false indulgence and physic.”

(Emma, by Jane Austen)

Homologous desensitization of GPCRs results from the binding of b-arrestins (b-arr) to agonist -occupied receptors following phosphorylation of the receptor by GRKs. b-arrestin binding sterically precludes coupling between the receptor and heterotrimeric G proteins, leading to termination of signaling by G proteins effectors.

(GPCR Desensitization Pathway, NCI Thesaurus/BIOCARTA)

These convictions must unquestionably have their own pain, and severe was its kind; but they precluded that pain which Lady Russell would suffer in entering the house again, and returning through the well-known apartments.

(Persuasion, by Jane Austen)