PRECLINICAL

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does preclinical mean? 

• PRECLINICAL (adjective)
  The adjective PRECLINICAL has 1 sense:

1. of or relating to the early phases of a disease when accurate diagnosis is not possible because symptoms of the disease have not yet appeared

  Familiarity information: PRECLINICAL used as an adjective is very rare.

 Dictionary entry details 

• PRECLINICAL (adjective)

Sense 1

Meaning:

Of or relating to the early phases of a disease when accurate diagnosis is not possible because symptoms of the disease have not yet appeared

Classified under:

Relational adjectives (pertainyms)

Synonyms:

preclinical; presymptomatic

Pertainym:

medical diagnosis (identification of a disease from its symptoms)

 Context examples 

“The preclinical state of the disease offers a window of opportunity for timely disease-modifying intervention,” Federoff says.

(Study Points to Possible Blood Test For Memory Decline, Alzheimer’s, NIH)

Drug development activites focused on preclinical trials and testing.

(Drug Development, Preclinical, NCI Thesaurus)

A group of pharmacokinetic parameters commonly investigated during preclinical drug development.

(ADME Study, NCI Thesaurus)

In the patients whose PET scans and cerebrospinal fluid showed preclinical Alzheimer's, the area at the center of the retina without blood vessels was significantly larger, suggesting less blood flow.

(Predicting Alzheimer's Disease May Be Possible Using Eye Exam, The Titi Tudorancea Bulletin)

Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types.

(Cobimetinib, NCI Thesaurus)

In preclinical trials, N-(5-tert-butyl-3-isoxazolyl)-N-(4-(4-pyridinyl)oxyphenyl)urea inhibited raf kinase, an enzyme capable of reversing the phenotype of ras-transformed cells and blocking tumor growth.

(N-(5-tert-butyl-3-isoxazolyl)-N-(4-(4-pyridinyl)oxyphenyl) Urea, NCI Thesaurus)

These included domains of cognitive functioning most likely to be affected in preclinical and early stages of dementia (e.g., attention, executive function, processing speed, and subjective memory function).

(Meditation, Music May Help Reverse Early Memory Loss in Adults, The Titi Tudorancea Bulletin)

Based on these preclinical findings, NIAID investigators designed an early stage clinical trial to test the safety and potential benefit of a treatment containing live R. mucosa in people with atopic dermatitis.

(Bacteria therapy for eczema shows promise in NIH study, National Institutes of Health)

Drug development activites focused on the phases preceding preclinical trials and testing.

(Drug Development, Experimental, NCI Thesaurus)

Preclinical studies designed to improve cancer treatment, with an emphasis on the discovery of new drugs and treatment strategies, selective targeting, development of new preclinical models, and understanding, preventing, and overcoming drug resistance.

(Biochemistry and Pharmacology Cancer Activity, NCI Thesaurus)