POTENTIATION

Pronunciation (US):

(GB):

 Dictionary entry overview: What does potentiation mean? 

• POTENTIATION (noun)
  The noun POTENTIATION has 1 sense:

1. (medicine) the synergistic effect of two drugs given simultaneously

  Familiarity information: POTENTIATION used as a noun is very rare.

 Dictionary entry details 

• POTENTIATION (noun)

Sense 1

Meaning:

(medicine) the synergistic effect of two drugs given simultaneously

Classified under:

Nouns denoting natural processes

Hypernyms ("potentiation" is a kind of...):

synergism; synergy (the working together of two things (muscles or drugs for example) to produce an effect greater than the sum of their individual effects)

Domain category:

medical specialty; medicine (the branches of medical science that deal with nonsurgical techniques)

Derivation:

potentiate (increase the effect of or act synergistically with (a drug or a physiological or biochemical phenomenon))

 Context examples 

This allele, which encodes APCL protein, plays a role in the potentiation of the Wnt protein signaling pathway.

(APC2 wt Allele, NCI Thesaurus)

This protein plays a role in both serine/threonine phosphorylation and the potentiation of mitogen-activated signaling pathways.

(Mitogen-Activated Protein Kinase Kinase Kinase 7, NCI Thesaurus)

This gene plays a regulatory role in synaptic functions and in the long-term potentiation of brain synapses.

(NTRK2 Gene, NCI Thesaurus)

The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability.

(Phenytoin, NCI Thesaurus)

This allele, which encodes leucine-rich glioma-inactivated protein 1, may be involved in both the regulation of the proliferation of various types of brain cells and neurotransmitter signal potentiation.

(LGI1 wt Allele, NCI Thesaurus)

Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation.

(Carbamazepine, NCI Thesaurus)

This allele, which encodes GRB2-associated-binding protein 2, plays a role in hematopoetic cell receptor signal potentiation.

(GAB2 wt Allele, NCI Thesaurus)

Two key features of the immune system are the clonal expansion of B cells and T cells in response to antigens, and the potentiation of future immune responses by long-lived memory cells.

(OX40 Signaling Pathway, NCI Thesaurus/BIOCARTA)

This leads to a reduction in posttetanic potentiation at synapses, an inhibition of repetitive firing of action potentials and ultimately inhibits the spread of seizure activity.

(Phenytoin sodium, NCI Thesaurus)

Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory.

(Long-Term Potentiation Pathway, NCI Thesaurus/KEGG)