PI

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does PI mean? 

• PI (noun)
  The noun PI has 5 senses:

1. the ratio of the circumference to the diameter of a circle; approximately equal to 3.14159265358979323846...

2. someone who can be employed as a detective to collect information

3. the scientist in charge of an experiment or research project

4. the 16th letter of the Greek alphabet

5. an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs

  Familiarity information: PI used as a noun is common.

 Dictionary entry details 

• PI (noun)

Sense 1

Meaning:

The ratio of the circumference to the diameter of a circle; approximately equal to 3.14159265358979323846...

Classified under:

Nouns denoting quantities and units of measure

Hypernyms ("pi" is a kind of...):

transcendental number (an irrational number that is not algebraic)

Sense 2

Meaning:

Someone who can be employed as a detective to collect information

Classified under:

Nouns denoting people

Synonyms:

operative; PI; private detective; private eye; private investigator; shamus; sherlock

Hypernyms ("PI" is a kind of...):

detective (an investigator engaged or employed in obtaining information not easily available to the public)

Hyponyms (each of the following is a kind of "PI"):

hotel detective; house detective; house dick (a private detective employed by a hotel or retail store)

inquiry agent (a private detective)

store detective (a private detective employed by a merchant to stop pilferage)

Sense 3

Meaning:

The scientist in charge of an experiment or research project

Classified under:

Nouns denoting people

Synonyms:

PI; principal investigator

Hypernyms ("PI" is a kind of...):

scientist (a person with advanced knowledge of one or more sciences)

Sense 4

Meaning:

The 16th letter of the Greek alphabet

Classified under:

Nouns denoting communicative processes and contents

Hypernyms ("pi" is a kind of...):

alphabetic character; letter; letter of the alphabet (the conventional characters of the alphabet used to represent speech)

Holonyms ("pi" is a member of...):

Greek alphabet (the alphabet used by ancient Greeks)

Sense 5

Meaning:

An antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs

Classified under:

Nouns denoting man-made objects

Synonyms:

PI; protease inhibitor

Hypernyms ("PI" is a kind of...):

antiviral; antiviral agent; antiviral drug (any drug that destroys viruses)

Hyponyms (each of the following is a kind of "PI"):

Crixivan; indinavir (a protease inhibitor (trade name Crixivan) used for treating HIV)

nelfinavir; Viracept (a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs)

Norvir; ritonavir (a protease inhibitor (trade name Norvir) used in treating HIV)

Invirase; saquinavir (a weak protease inhibitor (trade name Invirase) used in treating HIV)

Holonyms ("PI" is a part of...):

drug cocktail; HAART; highly active antiretroviral therapy (a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV)

 Context examples 

The PI also analyzes the data and reports the results of the trial or grant research.

(PI, NCI Dictionary)

Pain Intensity (PI v1) Average pain intensity for various time periods of evaluation.

(PI - Average Pain Intensity For Various Time Periods of Evaluation, NCI Thesaurus)

Pain Intensity (PI v1) Least pain intensity for various time periods of evaluation.

(PI - Least Pain Intensity For Various Time Periods of Evaluation, NCI Thesaurus)

Pain Intensity (PI v1) Maximum pain intensity for various time periods of evaluation.

(PI - Maximum Pain Intensity For Various Time Periods of Evaluation, NCI Thesaurus)

Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity.

(Ixazomib, NCI Thesaurus)

Upstream activation of PI 3 kinase activity that leads to oncogenic transformation can be blocked by inhibition of mTOR by rapamycin.

(mTOR Signaling Pathway BioCarta, NCI Thesaurus/BIOCARTA)

Phosphatidylinositol (PtdIns), the precursor of all phosphoinositides (PI), constitutes less than 10% of the total lipid in eukaryotic cell membranes.

(Phosphoinositide Pathway, NCI Thesaurus/BIOCARTA)

Heparanase inhibitor PI-88 inhibits the endo-beta-D-glucuronidase heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate proteoglycans in extracellular matrices, an important step in the metastatic process.

(Phosphomannopentaose Sulfate, NCI Thesaurus)

They chose from 3 distinct subclasses of β-lactam compounds that target different aspects of the cell wall synthesis machinery in MRSA: meropenem, piperacillin, and tazobactam (ME/PI/TZ).

(Antibiotic Combinations May Combat MRSA Infections, NIH)

When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked.

(Extracellular Matrix Binding Pathway, NCI Thesaurus/BIOCARTA)