PHASE I

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does phase I mean? 

• PHASE I (noun)
  The noun PHASE I has 1 sense:

1. a clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained

  Familiarity information: PHASE I used as a noun is very rare.

 Dictionary entry details 

• PHASE I (noun)

Sense 1

Meaning:

A clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained

Classified under:

Nouns denoting acts or actions

Synonyms:

phase I; phase I clinical trial

Hypernyms ("phase I" is a kind of...):

clinical test; clinical trial (a rigorously controlled test of a new drug or a new invasive medical device on human subjects; in the United States it is conducted under the direction of the FDA before being made available for general clinical use)

 Context examples 

Any natural or synthetic substance that inhibits the activity of any phase I metabolic enzyme.

(Phase I Enzymes Inhibitor, NCI Thesaurus)

An immunomodulator, 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride, used in a phase I study for possible immunostimulatory effects in colorectal cancer.

(CL 246738, NCI Thesaurus)

Phase II detoxification enzymes, such as glutathione-S-transferase (GST), glucuronyl transferase, acyl transferase, or sulfotransferase, catalyze conjugation reactions of xenobiotics or metabolites formed in phase I reactions.

(Phase II Enzymes Inducer, NCI Thesaurus)

Because little is known about the possible risks and benefits of the treatments being tested, phase I trials usually include only a small number of patients who have not been helped by other treatments.

(phase I trial, NCI Dictionary)

Preclinical, phase I, and phase II studies of both monoclonal antibodies to VEGF and blockers of the VEGF receptor tyrosine kinase pathway indicate that these agents are safe and offer potential clinical utility in patients with hematologic malignancies.

(Angiogenesis Pathway, NCI Thesaurus/BIOCARTA)

Design, identification, synthesis, extraction, purification, modification, or characterization of potential anticancer agents; studies of their metabolism, distribution, excretion, physiological effects, molecular interactions, structural analysis, toxicity, mechanism of action, antitumor effects in vivo (nonhuman species) or in vitro (human or nonhuman), and phase I and phase II clinical trials.

(Drug Development, NCI Thesaurus)

It was first announced as a preclinical development candidate in 2012, and in 2014, it was the first new anti-malarial candidate to enter phase I human studies in Africa when clinical trials began at the UCT Clinical Research Centre.

(Antimalarial candidate holds promise as a single dose, SciDev.Net)

The cytochrome P450 (CYP450) mono-oxygenase family of enzymes catalyzes the majority of the phase I reactions.

(Phase I Enzymes Inhibitor, NCI Thesaurus)