ONCOGENE

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 Dictionary entry overview: What does oncogene mean? 

• ONCOGENE (noun)
  The noun ONCOGENE has 1 sense:

1. a gene that disposes normal cells to change into cancerous tumor cells

  Familiarity information: ONCOGENE used as a noun is very rare.

 Dictionary entry details 

• ONCOGENE (noun)

Sense 1

Meaning:

A gene that disposes normal cells to change into cancerous tumor cells

Classified under:

Nouns denoting body parts

Synonyms:

oncogene; transforming gene

Hypernyms ("oncogene" is a kind of...):

cistron; factor; gene ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity)

 Context examples 

This gene is involved in the regulation of gene expression and is proposed to act as an oncogene in a broad variety of leukemias as well as colon, pancreatic and prostate carcinomas.

(MIR106A Gene, NCI Thesaurus)

This gene is involved in the regulation of gene expression and acts as an oncogene in hepatocellular, ovarian, breast, lung, thyroid and prostate carcinomas as well as melanoma and glioblastoma multiforme.

(MIR221 Gene, NCI Thesaurus)

Acts as an oncogene in breast, lung, thyroid and prostate carcinomas as well as metastatic melanoma and glioblastoma multiforme.

(MIR222 Gene, NCI Thesaurus)

Point-mutation products of Ras proto-oncogene are found to associated with a broad spectrum of human carcinomas.

(Mutated Ras Peptide, NCI Thesaurus)

An inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity.

(MET Tyrosine Kinase Inhibitor SAR125844, NCI Thesaurus)

Cell adhesion molecule-related/down-regulated by oncogenes (1287 aa, ~139 kDa) is encoded by the human CDON gene.

(Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes, NCI Thesaurus)

The technique is used to detect overexpression of c-Myc oncogene which leads to cancer.

(c-Myc Staining Method, NCI Thesaurus)

Cancer gene mutations include both activation of oncogenes and inactivation of tumor suppressor genes.

(Cancer Gene Mutation, NCI Thesaurus)

This oncogene is involved in cell cycle control.

(CDC25A Gene, NCI Thesaurus)

However, when URI is not present in these stem cells, the well-known oncogene c-MYC is overexpressed, which leads to cell proliferation and increases susceptibility of these cells to radiation damage.

(New Way Discovered for Protecting against High-Dose Radiation Damage, The Titi Tudorancea Bulletin)