NPC

Pronunciation (US):

(GB):

 Dictionary entry overview: What does NPC mean? 

• NPC (noun)
  The noun NPC has 1 sense:

1. an agency that serves as the focal point for all Intelligence Community activities related to nonproliferation of weapons of mass destruction and their missile delivery systems

  Familiarity information: NPC used as a noun is very rare.

 Dictionary entry details 

• NPC (noun)

Sense 1

Meaning:

An agency that serves as the focal point for all Intelligence Community activities related to nonproliferation of weapons of mass destruction and their missile delivery systems

Classified under:

Nouns denoting groupings of people or objects

Synonyms:

Nonproliferation Center; NPC

Hypernyms ("NPC" is a kind of...):

agency; authority; bureau; federal agency; government agency; office (an administrative unit of government)

Holonyms ("NPC" is a part of...):

Central Intelligence Agency; CIA (an independent agency of the United States government responsible for collecting and coordinating intelligence and counterintelligence activities abroad in the national interest; headed by the Director of Central Intelligence under the supervision of the President and National Security Council)

 Context examples 

NPC is comprised of approximately 50 unique proteins collectively known as nucleoporins.

(Nuclear Pore Complex, NCI Thesaurus)

The ras-like GTPase Ran that regulates nucleocytoplasmic transport through the nuclear pore complex (NPC) during interphase also regulates the formation of the mitotic spindle.

(Mitotic Spindle Regulation Pathway, NCI Thesaurus/BIOCARTA)

NPC-1C contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype.

(Ensituximab, NCI Thesaurus)

The NUP98 C-terminal RNA-binding domain also contains NPC target sequences, a novel protein fold, and an autocatalytic protease.

(Nucleoporin 98kD, NCI Thesaurus)

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins.

(Nucleoporin, NCI Thesaurus)

Among a limited set of viral antigens expressed by NPC cells, LMP1 and LMP2 are weak immunogens which, nevertheless, are capable of inducing a T-lymphocyte response.

(Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes, NCI Thesaurus)

NPC functions in the nuclear transport of protein and RNA.

(Nuclear Pore Complex, NCI Thesaurus)

Anti-CPAA monoclonal antibody NPC-1C binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells.

(Ensituximab, NCI Thesaurus)

NPC targeting of NUP96 and NUP98 is cleavage dependent, which may regulate assembly of the NPC, comprised of nearly fifty nucleoporins involved in signal-mediated nuclear import and export of protein and RNA.

(Nucleoporin 98kD, NCI Thesaurus)

Autologous dendritic cells and EBV-infected lymphoblastoid cell lines (LCL) from patients with EBV-positive nasopharyngeal carcinoma (NPC) are transduced with an LMP1/LMP2-expressing adenoviral vector, are irradiated, and then are used to stimulate and expand autologous CTL to produce autologous LMP1-/LMP2-specific CTL ex vivo.

(Autologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes, NCI Thesaurus)