NORETHINDRONE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does norethindrone mean? 

• NORETHINDRONE (noun)
  The noun NORETHINDRONE has 1 sense:

1. a synthetic progestational hormone (trade name Norlutin) used in oral contraceptives and to treat endometriosis

  Familiarity information: NORETHINDRONE used as a noun is very rare.

 Dictionary entry details 

• NORETHINDRONE (noun)

Sense 1

Meaning:

A synthetic progestational hormone (trade name Norlutin) used in oral contraceptives and to treat endometriosis

Classified under:

Nouns denoting substances

Synonyms:

norethandrolone; norethindrone; norethindrone acetate; Norlutin

Hypernyms ("norethindrone" is a kind of...):

progestin; progestogen (any of a group of steroid hormones that have the effect of progesterone)

Holonyms ("norethindrone" is a substance of...):

Loestrin (trade name for an oral contraceptive containing estradiol and norethindrone)

Micronor (trade name for and oral contraceptive containing the progestin compound norethindrone)

Modicon (trade name for an oral contraceptive containing estradiol and norethindrone)

Norinyl (trade name for an oral contraceptive containing norethindrone and mestranol)

Norlestrin (trade name for an oral contraceptive containing estradiol and norethindrone)

Nor-Q-D (trade name for an oral contraceptive containing norethindrone)

Ovocon (trade name for an oral contraceptive containing estradiol and norethindrone)

 Context examples 

A derivative of the synthetic progestin norethindrone with antiprogesterone activity.

(Mifepristone, NCI Thesaurus)

Norethindrone binds to the progesterone intracellular receptors in the reproductive system and the resultant activated complex interacts with specific DNA sites.

(Norethindrone, NCI Thesaurus)

The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities.

(Norethindrone Acetate, NCI Thesaurus)

An orally bioavailable tablet formulation containing the semisynthetic estrogen estradiol in combination with the acetate form of the synthetic progestin norethindrone, with estrogenic and progesteronic activities.

(Estradiol/Norethindrone Acetate Tablet, NCI Thesaurus)

Ethinyl estradiol inhibits the release of follicle stimulating hormone (FSH), thus suppressing the development of ovarian follicle; norethindrone levonorgestrel inhibits the release of luteinizing hormone (LH), thus preventing ovulation.

(Ethinyl Estradiol/Norethindrone, NCI Thesaurus)

The preparation usually contains conjugated estrogens, estradiol, or estrone sulfate and a progesterone derivative, such as medroxyprogesterone, norgestimate or norethindrone, which is used to offset an increased risk of estrogen-induced endometrial cancer.

(Hormone Replacement Preparation, NCI Thesaurus)

Administration of estradiol/norethindrone acetate may abrogate vasomotor symptoms associated with menopause and prevent bone loss associated with the postmenopause.

(Estradiol/Norethindrone Acetate Tablet, NCI Thesaurus)

As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation.

(Norethindrone Acetate, NCI Thesaurus)

Norethindrone is a synthetic progestogen.

(Ethinyl Estradiol/Norethindrone, NCI Thesaurus)

Norethindrone binds to the intracellular progesterone receptors in the reproductive system and the activated ligand/receptor complex interacts with specific DNA response elements, resulting in an alteration in protein synthesis; inhibition of luteinizing hormone (LH) and follicle stimulating hormone (FSH) release; inhibition of ovulation; an increase in cervical mucus production; and induction of the secretory phase of the endometrial cycle.

(Estradiol/Norethindrone Acetate Tablet, NCI Thesaurus)