NONFUNCTIONAL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does nonfunctional mean? 

• NONFUNCTIONAL (adjective)
  The adjective NONFUNCTIONAL has 2 senses:

1. not having or performing a function

2. not performing or able to perform its regular function

  Familiarity information: NONFUNCTIONAL used as an adjective is rare.

 Dictionary entry details 

• NONFUNCTIONAL (adjective)

Sense 1

Meaning:

Not having or performing a function

Similar:

nonstructural (not structural)

cosmetic; decorative; ornamental (serving an esthetic rather than a useful purpose)

Also:

unserviceable (not ready for service)

Attribute:

function; purpose; role; use (what something is used for)

Antonym:

functional (designed for or capable of a particular function or use)

Sense 2

Meaning:

Not performing or able to perform its regular function

Synonyms:

malfunctioning; nonfunctional

Context example:

a malfunctioning valve

Similar:

amiss; awry; haywire; wrong (not functioning properly)

bad; defective (not working properly)

out of whack (out of balance or out of adjustment)

run-down (having the spring unwound)

 Context examples 

Nonfunctional pancreatic endocrine tumors do not make extra amounts of hormones, but they may cause symptoms as they grow and spread.

(Pancreatic endocrine tumor, NCI Dictionary)

Nonfunctional pancreatic neuroendocrine tumors do not make extra amounts of hormones, but they may cause symptoms as they grow and spread.

(Pancreatic neuroendocrine tumor, NCI Dictionary)

Nonfunctional pancreatic endocrine cancers do not make extra amounts of hormones, but they may cause symptoms as they grow and spread.

(Pancreatic endocrine cancer, NCI Dictionary)

Nonfunctional islet cell tumors do not make extra amounts of hormones, but they may cause symptoms as they grow and spread.

(Islet cell tumor, NCI Dictionary)

According to the presence or absence of clinical syndromes that result from hormone hypersecretion, pancreatic neuroendocrine tumors are classified either as functional or nonfunctional.

(Pancreatic neuroendocrine tumor, NCI Thesaurus)

Nonfunctional islet cell carcinomas do not make extra amounts of hormones, but they may cause symptoms as they grow and spread.

(Islet cell carcinoma, NCI Dictionary)

Further investigation of tumors from patients resistant to immunotherapies showed that the apelin receptor protein was nonfunctional in some of them, indicating that the loss of this protein may limit the response to immunotherapy treatment.

(A new study identifies essential genes for cancer immunotherapy, National Institutes of Health)

Modification with the double cyclic peptide RGD-4C allows the virus to bind to cellular integrins, frequently expressed on the surfaces of ovarian cancer cells, instead of the coxsackie and adenovirus (CAR) receptor, which is often nonfunctional in ovarian cancer cells.

(Ad5.SSTR/TK.RGD, NCI Thesaurus)