NALOXONE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does naloxone mean? 

• NALOXONE (noun)
  The noun NALOXONE has 1 sense:

1. a potent narcotic antagonist (trade name Narcan) especially effective with morphine

  Familiarity information: NALOXONE used as a noun is very rare.

 Dictionary entry details 

• NALOXONE (noun)

Sense 1

Meaning:

A potent narcotic antagonist (trade name Narcan) especially effective with morphine

Classified under:

Nouns denoting man-made objects

Synonyms:

naloxone; Narcan

Hypernyms ("naloxone" is a kind of...):

narcotic antagonist (an antagonist used to counteract the effects of narcotics (especially to counteract the depression of respiration))

 Context examples 

The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity.

(Naloxone Hydrochloride, NCI Thesaurus)

Naltrexone is longer-acting and more potent compared to naloxone.

(Naltrexone, NCI Thesaurus)

Alvimopan is approximately three to nine times more potent than naloxone.

(Alvimopan, NCI Thesaurus)

Naloxone binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors in the CNS.

(Naloxone, NCI Thesaurus)

Participants who meditated during naloxone administration also had significantly greater reductions in pain intensity and unpleasantness than the control groups.

(Scientists discover non-opioid pain pathway in the brain, NIH)

An orally available formulation containing naloxol, a derivative of the opioid antagonist naloxone, conjugated with polyethylene glycol (PEG), with opioid-induced constipation (OIC)-relieving activity.

(Oral Pegylated Naloxol, NCI Thesaurus)

As naloxone is very poorly absorbed, this agent binds locally to opiate receptors in the GI tract, thereby preventing oxycodone from binding to these receptors.

(Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet, NCI Thesaurus)

It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction.

(Naltrexone hydrochloride, NLM, Medical Subject Headings)

No significant differences in reductions of pain intensity or pain unpleasantness were seen between the meditation plus naloxone and the meditation plus saline groups.

(Scientists discover non-opioid pain pathway in the brain, NIH)

Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence.

(Naloxone Hydrochloride, NCI Thesaurus)