MUTANT

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does mutant mean? 

• MUTANT (noun)
  The noun MUTANT has 2 senses:

1. (biology) an organism that has characteristics resulting from chromosomal alteration

2. an animal that has undergone mutation

  Familiarity information: MUTANT used as a noun is rare.

• MUTANT (adjective)
  The adjective MUTANT has 1 sense:

1. tending to undergo or resulting from mutation

  Familiarity information: MUTANT used as an adjective is very rare.

 Dictionary entry details 

• MUTANT (noun)

Sense 1

Meaning:

(biology) an organism that has characteristics resulting from chromosomal alteration

Classified under:

Nouns denoting people

Synonyms:

mutant; mutation; sport; variation

Hypernyms ("mutant" is a kind of...):

being; organism (a living thing that has (or can develop) the ability to act or function independently)

Domain category:

biological science; biology (the science that studies living organisms)

Hyponyms (each of the following is a kind of "mutant"):

freak; lusus naturae; monster; monstrosity (a person or animal that is markedly unusual or deformed)

Derivation:

mutant (tending to undergo or resulting from mutation)

mutate (undergo mutation)

Sense 2

Meaning:

An animal that has undergone mutation

Classified under:

Nouns denoting animals

Hypernyms ("mutant" is a kind of...):

animal; animate being; beast; brute; creature; fauna (a living organism characterized by voluntary movement)

Derivation:

mutant (tending to undergo or resulting from mutation)

mutate (undergo mutation)

• MUTANT (adjective)

Sense 1

Meaning:

Tending to undergo or resulting from mutation

Classified under:

Relational adjectives (pertainyms)

Context example:

a mutant gene

Pertainym:

mutation ((genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism)

Derivation:

mutant (an animal that has undergone mutation)

mutant ((biology) an organism that has characteristics resulting from chromosomal alteration)

mutate (undergo mutation)

 Context examples 

Each affected person had one mutant and one normal copy of the gene, while the unaffected family members had two normal copies of the gene.

(Researchers discover new autoinflammatory disease and uncover its biological cause, National Institutes of Health)

Mutant forms of c-Kit are often associated with tumor chemoresistance.

(Amuvatinib, NCI Thesaurus)

An immunoconjugate consisting of a human monoclonal antibody directed against the deletion-mutant of epidermal growth factor receptor, EGFRvIII, conjugated via a non-cleavable linker to the cytotoxic agent maytansinoid DM1, with potential antineoplastic activity.

(Anti-EGFRvIII Antibody Drug Conjugate AMG 595, NCI Thesaurus)

The gene therapy treatment, known as the mitochondrially targeted zinc finger-nuclease, or mtZFN, recognises and then eliminates the mutant mitochondrial DNA, based on the DNA sequence differences between healthy and mutant mitochondrial DNA.

(Mitochondrial diseases could be treated with gene therapy, The Titi Tudorancea Bulletin)

Transplanting the microbiota of regular-fed mutant mice to young mice boosted Prevotella levels and sped osteomyelitis.

(Diet Affects Autoinflammatory Disease Via Gut Microbes, NIH)

When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow.

(Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes, NCI Thesaurus)

Many tumor cells overexpress mutant p53 proteins, resulting in the loss of apoptosis regulation and abnormal cell proliferation.

(Mutant p53 Peptide Pulsed Dendritic Cell Vaccine, NCI Thesaurus)

Alternatively, mutant RAS directly stimulates BRAF, whereas mutant BRAF directly stimulates MEK.

(Papillary Thyroid Carcinoma Pathway, NCI Thesaurus/KEGG)

A modification of the standard polymerase chain reaction that increases the ability to preferentially amplify mutant alleles in the presence of an excess of wild-type molecules.

(Peptide Nucleic Acid Clamping, NCI Thesaurus)

This mutant MGMT protein, MGMTP140K, is resistant to the O6-benzylguanine (BG), an inhibitor of the wild type MGMT.

(MSCV (MGMTP140K) Retroviral Vector-Transduced CD34+ Autologous PBSC, NCI Thesaurus)