English Dictionary |
MULTIVALENT
Pronunciation (US): | (GB): |
Dictionary entry overview: What does multivalent mean?
• MULTIVALENT (adjective)
The adjective MULTIVALENT has 3 senses:
1. used of the association of three or more homologous chromosomes during the first division of meiosis
2. having more than one valence, or having a valence of 3 or higher
3. having many values, meanings, or appeals
Familiarity information: MULTIVALENT used as an adjective is uncommon.
Dictionary entry details
Sense 1
Meaning:
Used of the association of three or more homologous chromosomes during the first division of meiosis
Attribute:
valence; valency ((biology) a relative capacity to unite or react or interact as with antigens or a biological substrate)
Domain category:
genetic science; genetics (the branch of biology that studies heredity and variation in organisms)
Antonym:
bivalent (used of homologous chromosomes associated in pairs in synapsis)
univalent (used of a chromosome that is not paired or united with its homologous chromosome during synapsis)
Sense 2
Meaning:
Having more than one valence, or having a valence of 3 or higher
Synonyms:
multivalent; polyvalent
Attribute:
valence; valency ((chemistry) a property of atoms or radicals; their combining power given in terms of the number of hydrogen atoms (or the equivalent))
Domain category:
chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)
Derivation:
multivalence; multivalency ((chemistry) the state of having a valence greater than two)
Sense 3
Meaning:
Having many values, meanings, or appeals
Synonyms:
multi-valued; multivalent
Context example:
subtle, multivalent allegory
Similar:
ambiguous (having more than one possible meaning)
Context examples
A multivalent vaccine comprised of Globo H (Globo H Hexasaccharide 1), GM2, Lewis-y, MUC1-32-mer, TF(c), and Tn(c) antigens conjugated with Keyhole Limpet Hemocyanin, an immunomodulator, plus QS21, an immune enhancer.
(Globo H-GM2-Lewis-y-MUC1-32-mer-TF(c)-Tn(c)-KLH Conjugate Vaccine/QS21, NCI Thesaurus)
An autologous, multivalent dendritic cell vaccine targeting ovarian cancer with potential immunostimulating and antineoplastic activities.
(DC-OVA Vaccine, NCI Thesaurus)
A synthetic, multivalent, lysine-rich, pseudopeptide and nucleolin antagonist with potential anti-angiogenic, antineoplastic and pro-apoptotic activities.
(Nucleolin Antagonist IPP-204106N, NCI Thesaurus)
Vaccination with this multivalent vaccine may induce production of IgG and IgM antibodies as well as an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumors expressing these antigens.
(Globo H-GM2-Lewis-y-MUC1-32-mer-TF(c)-Tn(c)-KLH Conjugate Vaccine, NCI Thesaurus)
Multivalent Fab' antibody fragments may exhibit improved retention and internalization properties compared to their parent IgGs.
(Pegylated Anti-GFR Antibody Fragment, NCI Thesaurus)
CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins.
(CTCF Pathway, NCI Thesaurus/BIOCARTA)
A cancer vaccine, containing human-specific large multivalent immunogens (LMIs) isolated from the membrane fraction of cells from a breast cancer cell line, with potential immunostimulatory and antineoplastic activities.
(Allogeneic Large Multivalent Immunogen Breast Cancer Vaccine, NCI Thesaurus)
Upon administration, allogeneic large multivalent immunogen melanoma vaccine LP2307 may stimulate a CD8+ cytotoxic T lymphocyte (CTL) response against melanoma tumor cells that express melanoma-specific LMI.
(Allogeneic Large Multivalent Immunogen Melanoma Vaccine LP2307, NCI Thesaurus)
A multivalent antineoplastic vaccine comprised of the bcr-abl oncogene breakpoint fusion peptide that elicits a bcr-abl specific T-cell immune response.
(BCR-ABL Peptide Vaccine, NCI Thesaurus)
An orally available, multivalent herbal formulation containing a novel mixture of whole extracts from three commonly used Chinese medicinal herbs Ganoderma lucidum (lingzhi mushroom), Salvia miltiorrhiza (Chinese sage, or danshen) and Scutellaria barbata (ban zhi lian), with potential immunomodulating, antiangiogenic, anti-inflammatory, antiproliferative and antiviral activities.
(Multifunctional/Multitargeted Anticancer Agent OMN54, NCI Thesaurus)
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