METFORMIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does metformin mean? 

• METFORMIN (noun)
  The noun METFORMIN has 1 sense:

1. an antidiabetic drug (trade name Glucophage) prescribed to treat type II diabetes

  Familiarity information: METFORMIN used as a noun is very rare.

 Dictionary entry details 

• METFORMIN (noun)

Sense 1

Meaning:

An antidiabetic drug (trade name Glucophage) prescribed to treat type II diabetes

Classified under:

Nouns denoting man-made objects

Synonyms:

Glucophage; metformin

Hypernyms ("metformin" is a kind of...):

antidiabetic; antidiabetic drug (a drug used to treat diabetes mellitus)

 Context examples 

The hydrochloride salt of the biguanide metformin with antihyperglycemic and potential antineoplastic activities.

(Metformin hydrochloride, NCI Thesaurus)

Metformin hydrochloride is a type of antidiabetic agent.

(Metformin hydrochloride, NCI Dictionary)

Metformin is not metabolized and is excreted unchanged by the kidneys.

(Metformin, NCI Thesaurus)

Metformin is a type of antidiabetic agent.

(Metformin, NCI Dictionary)

Also called metformin hydrochloride.

(Glucophage, NCI Dictionary)

Based on their mechanism of action, this class of agents can be classified to the following groups: directly acting insulomimetics, which activates insulin receptors; indirectly acting insulinomimetics, which increase insulin release such as sulfonylureas or which potentiate the effect of insulin such as metformin; those act directly on the metabolism of glucose such as inhibitors of glucosidases and inhibitors of aldose reductase.

(Anti-diabetic Agent, NCI Thesaurus)

Metformin may exert antineoplastic effects through AMPK-mediated or AMPK-independent inhibition of mammalian target of rapamycin (mTOR), which is up-regulated in many cancer tissues.

(Metformin hydrochloride, NCI Thesaurus)

Metformin is associated with a very low incidence of lactic acidosis.

(Metformin, NCI Thesaurus)

Metformin inhibits complex I (NADPH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain, thereby increasing the cellular AMP to ATP ratio and leading to activation of AMP-activated protein kinase (AMPK) and regulating AMPK-mediated transcription of target genes.

(Metformin hydrochloride, NCI Thesaurus)