MERCAPTOPURINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does mercaptopurine mean? 

• MERCAPTOPURINE (noun)
  The noun MERCAPTOPURINE has 1 sense:

1. a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia

  Familiarity information: MERCAPTOPURINE used as a noun is very rare.

 Dictionary entry details 

• MERCAPTOPURINE (noun)

Sense 1

Meaning:

A drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia

Classified under:

Nouns denoting man-made objects

Synonyms:

mercaptopurine; Purinethol

Hypernyms ("mercaptopurine" is a kind of...):

antimetabolite (an antineoplastic drug that inhibits the utilization of a metabolite)

immune suppressant drug; immunosuppressant; immunosuppressive; immunosuppressive drug; immunosuppressor (a drug that lowers the body's normal immune response)

 Context examples 

The anhydrous form of mercaptopurine, a thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities.

(Mercaptopurine Anhydrous, NCI Thesaurus)

An oral suspension containing the thiopurine-derivative antimetabolite 6-mercaptopurine, with potential antineoplastic activity.

(Mercaptopurine Oral Suspension, NCI Thesaurus)

Cytoplasmic Hypoxanthine Phosphoribosyltransferases (Purine/Pyrimidine Phosphoribosyltransferase Family) catalyze the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate.

(Hypoxanthine Phosphoribosyltransferase, NCI Thesaurus)

Mercaptopurine stops cells from dividing and may kill cancer cells.

(Mercaptopurine, NCI Dictionary)

A S-substituted analog of mercaptopurine and purine antagonist with cytostatic activity.

(Butocin, NCI Thesaurus)

Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences.

(Azathioprine sodium, NCI Thesaurus)

In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis.

(Mercaptopurine, NCI Thesaurus)

Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis.

(Azathioprine, NCI Thesaurus)

Upon oral administration, mercaptopurine is metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) to its active metabolite 6-thioinosine monophosphate (TIMP); TIMP inhibits nucleotide interconversions and de novo purine ribonucleotide synthesis, which both blocks the formation of purine nucleotides and inhibits DNA synthesis.

(Mercaptopurine Oral Suspension, NCI Thesaurus)

Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis.

(Mercaptopurine, NCI Thesaurus)