MELPHALAN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does melphalan mean? 

• MELPHALAN (noun)
  The noun MELPHALAN has 1 sense:

1. antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies

  Familiarity information: MELPHALAN used as a noun is very rare.

 Dictionary entry details 

• MELPHALAN (noun)

Sense 1

Meaning:

Antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies

Classified under:

Nouns denoting man-made objects

Synonyms:

Alkeran; melphalan

Hypernyms ("melphalan" is a kind of...):

antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)

 Context examples 

A regimen consisting of melphalan and prednisone used as induction treatment for multiple myeloma.

(MP-Myeloma Regimen, NCI Thesaurus)

A regimen consisting of melphalan, prednisone and bortezomib used for the treatment of multiple myeloma.

(MPB Regimen, NCI Thesaurus)

This results in the specific release and accumulation of the active metabolite melphalan in cancer cells.

(Melphalan-Flufenamide Prodrug, NCI Thesaurus)

A dose-reduced variant of the BEAM conditioning regimen used in the transplant setting, consisting of carmustine, etoposide, cytarabine, and melphalan and used for the treatment of relapsed or refractory Hodgkin's lymphoma.

(Mini-BEAM Regimen, NCI Thesaurus)

A regimen consisting of melphalan, prednisone and thalidomide used as induction therapy for multiple myeloma.

(MPT Regimen, NCI Thesaurus)

The addition of sulfobutyl ether beta-cyclodextrin to the formulation improves the solubility, stability and ease of use of melphalan; cyclodextrins are cyclic dextrins derived from starch.

(Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex, NCI Thesaurus)

The meta form of the levo isomer melphalan, an alkylating nitrogen mustard with potential antineoplastic activity.

(Metamelfalan, NCI Thesaurus)

An L-leucine derivative of melphalan with antineoplastic activity.

(Asaley, NCI Thesaurus)

A dimethane sulfonate derivative and alkylating agent with a structure similar to other alkylating agents such as chlorambucil, busulfan and melphalan, with potential antineoplastic activity.

(Benzaldehyde Dimethane Sulfonate, NCI Thesaurus)

Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

(Melphalan, NCI Thesaurus)